I've been on Zoloft 50mgs daily for over a year now, because the withdrawal effects are too much to deal with. I hate it because it doesn't help my depression but I'm stuck on it. I also take around .25-.5 mg bupenorphine daily but just ran out. I have a script for 30 tabs of 50 mg tramadol and was gonna fill it to ease my bupe withdrawalfor a few days till iI can get more. But after reading some info about the danger of mixing the trams and Zoloft im having second thoughts.... any advice? If I did take the trams I would definitely go easy, not more than 200 mg per dose. Also any advice on getting of the Zoloft would be appreciated as I really hate the side effects especially while it gives me no benefit with depression.Thanks.