Pseudonemesis
Greenlighter
- Joined
- May 17, 2011
- Messages
- 5
Alpha Agonists
There is a class of drugs that specifically ligate a-adrenaline receptors in in the frontal cortex (IIRC). Clonidine and guanfacine are both effective a-adrenergic agonists. Their primary effects, IMHO, is clarity of thought and blood pressure drop. IMHO, they are better than benzos at stopping panic attacks unrelated to drug use (their are better 5HT2A receptor antagonists for that). They are slightly addictive though cause no euphoria or typical non-specific adrenaline agonists, if you are on them for ADD and high blood pressure you have to ween yourself off of them or you can get irritable.
SWIM takes them regularly along with remeron daily for ADD BP and finds that weening himself off 2 days before a trip or roll give him more mileage from his stash, as long as the doses are really low (as to not build tolerance 10-50mg methylone, 1-3mgs of 2C-I, 3mgs of JWH-210 orally). SWIM says he keeps the remeron dosage regular regardless of dosing with RC's. All of the RC's are taken long before his circadian rhythm has established the beginning of his sleep period, allowing the trip roll run its course, and then even after all of after effects from dosing early morning have worn off takes remeron. If you do it right you will gain no tolerance and as little as 10mg of methylone , 1mg 2C-I and 3mgs of 210 orally can be felt. The combination of the the three at these low dosages when you don't have any tolerance is fucking awesome, nothing like the mind-numb, glue you to the floor feeling of 150mg of methylone and 50mg of 4-mmc, but you can't do this everyday without developing tolerance.
It seems as though if you are working with your circadian rhythm and are taking drugs to increase axonal neurotransmitter concentrations that you can actually get better results then you had the last day. It is almost as something is upregulating maybe serotonin biosynthesis or some other neurotransmitter. SWIM swears he is getting higher than when he started this as long as the methylone doesn't approach 50mgs on a regular basis.
Anyone know of any studies which have been conducted on this? I have heard of studies that point to the fact that prozac taken post roll is effective at reducing neurotoxic effect, could this sorta be like that except using remeron?
I would love to see an academic study being done using this regiment or something similar, SWIM swears that this is one thing that if used in moderation might be better for you.
As for alpha agonists building tolerance SWIM says that the same does daily is all he needs unless he wants to dose some RCs then he will forego the morning before's dose.
There is a class of drugs that specifically ligate a-adrenaline receptors in in the frontal cortex (IIRC). Clonidine and guanfacine are both effective a-adrenergic agonists. Their primary effects, IMHO, is clarity of thought and blood pressure drop. IMHO, they are better than benzos at stopping panic attacks unrelated to drug use (their are better 5HT2A receptor antagonists for that). They are slightly addictive though cause no euphoria or typical non-specific adrenaline agonists, if you are on them for ADD and high blood pressure you have to ween yourself off of them or you can get irritable.
SWIM takes them regularly along with remeron daily for ADD BP and finds that weening himself off 2 days before a trip or roll give him more mileage from his stash, as long as the doses are really low (as to not build tolerance 10-50mg methylone, 1-3mgs of 2C-I, 3mgs of JWH-210 orally). SWIM says he keeps the remeron dosage regular regardless of dosing with RC's. All of the RC's are taken long before his circadian rhythm has established the beginning of his sleep period, allowing the trip roll run its course, and then even after all of after effects from dosing early morning have worn off takes remeron. If you do it right you will gain no tolerance and as little as 10mg of methylone , 1mg 2C-I and 3mgs of 210 orally can be felt. The combination of the the three at these low dosages when you don't have any tolerance is fucking awesome, nothing like the mind-numb, glue you to the floor feeling of 150mg of methylone and 50mg of 4-mmc, but you can't do this everyday without developing tolerance.
It seems as though if you are working with your circadian rhythm and are taking drugs to increase axonal neurotransmitter concentrations that you can actually get better results then you had the last day. It is almost as something is upregulating maybe serotonin biosynthesis or some other neurotransmitter. SWIM swears he is getting higher than when he started this as long as the methylone doesn't approach 50mgs on a regular basis.
Anyone know of any studies which have been conducted on this? I have heard of studies that point to the fact that prozac taken post roll is effective at reducing neurotoxic effect, could this sorta be like that except using remeron?
I would love to see an academic study being done using this regiment or something similar, SWIM swears that this is one thing that if used in moderation might be better for you.
As for alpha agonists building tolerance SWIM says that the same does daily is all he needs unless he wants to dose some RCs then he will forego the morning before's dose.
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