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adrenergic agonists

S

shir

Greenlighter
Joined
Dec 22, 2009
Messages
32
Hello
Is there any drugs that act direct on the adrenergic receptors as agonist, mainlt on the alpha-1 to improve the mood and energy, and of course it's have to cross the bbb.

ps. Im not talking about drugs that act on those receptors through NRI for example, im talking about direct action on the adrenergic receptors. Thanks
 
Is there even any evidence for a1 agonists to do that in a useful manner (increase mood/energy)? I'm not talking the fight/flight adrenaline response.

I look at that list of stuff on wiki and none of them sound even slightly recreational.

I actually did get the methylnorepinephrine shot in my gums to relieve pain so they could drill at the dentist once many years ago, and while it did give me a short-term increase to heart rate and some mild euphoria, it wasn't something I would want to last very long or do more than that one time. Dentist nitrous was way better...
 
Swerlz said:
http://en.wikipedia.org/wiki/Alpha-adrenergic_agonist


gooogle?
Click to expand...
yeah i know google but i need to find drugs that also cross the bbb. Haven't found anything

PsychedelicPeptide said:
Is there even any evidence for a1 agonists to do that in a useful manner (increase mood/energy)? I'm not talking the fight/flight adrenaline response.

I look at that list of stuff on wiki and none of them sound even slightly recreational.

I actually did get the methylnorepinephrine shot in my gums to relieve pain so they could drill at the dentist once many years ago, and while it did give me a short-term increase to heart rate and some mild euphoria, it wasn't something I would want to last very long or do more than that one time. Dentist nitrous was way better...
Click to expand...

Hi
I assume that from stuff i read on the internet but i would like to know if there is any drugs that cross the bbb and acting as norepinephrine(increase energy and mood) since NRIs working the opposite on me (causing a serious depression and causing me so weakness)
I belive i have problem with NE that i need to fing something that work like NE and crossing bbb.
 
Try an a2 antagonist like yohimbine. Most adrenergic agents are useful only as decongestants.

Synephrine, octopamine, ephedrine, etc could be worth a shot too.

Caffeine doesn't have adrenergic activity. It's an adenosine antagonist.
 
sekio said:
Try an a2 antagonist like yohimbine. Most adrenergic agents are useful only as decongestants.

Synephrine, octopamine, ephedrine, etc could be worth a shot too.

Caffeine doesn't have adrenergic activity. It's an adenosine antagonist.
Click to expand...

Yes, nice knowledge, caffeine is adenodine antagonist. I've tried already a2 antagonists, it dosn't work for me, i tried mirtszapine and mianserin.
I belive i have low activity in the vesicular monoamine transporter (vmat), the thing that insert the NE to the synaftic vesicles, maybe im wrong, all i know that NRI works the opposite on me and a2 antagonists don't work so im trying to find something that works like NE as agonist to the receptors, i think mainly as a1 agonist.
 
Try something more selective for a2 like yohimbe/yohimbine. Mirtazepine and mianserin are not selective and have activity at serotonin/histamine sites too. In fact they are not considered selective a2 antagonists but instead NaSSA (Noradrenergic and specific serotonergixc antidepressant) which are not going to help at all. H1 and serotonin antagonism doesn't increase activity levels; it decreases them.

Most a1 selective agonists are fairly unpleasant to work with (elevated heart rate, blood pressure, vasoconstriction) and are far more useful as decongestants or for controlling heart rate, but as stated before, try one or more of the following: synephrine, octopamine, ephedrine, phenylephrine, oxymetazoline, xylometazoline, adrafinil, or modafinil. Oxymetazoline/xylometazoline are commonly used as decongestant nose sprays.

Expect development of tolerance with all agents in this class of drugs. You're not going to be able to keep popping ephedrine indefinitely.

What kind of NRI did you try, and at what dose? Most NRI drugs take a long period of administration to show effects and almost all of them will make you feel like shit unles you dose it right.
 
PsychedelicPeptide said:
I actually did get the methylnorepinephrine shot
Click to expand...

Ive got one too, it felt like a dysphoric thrill of shoplifting, which I fell asleep within muinutes.
Similar to when I last had ephedrine, I slept through stronger increase of BP than an amphetamine high. I remember waking up and being like "FUCK THIS."

or yohembi while addicted to opiates, pleasantly stimulated, only to wake up shortly after sleeping, burning up in opiate withdrawl that seemed to to perminantly change the state of withdrawl for me.
 
Why do you think you need something to that effects NE?? you still haven't said why you need an a1 agonist that can cross the bbb... yes i know you said mood/energy, but to my knowledge.. NE doesn't solely control that.. I would think that would be a dopamine kind of deal


have you tried Modafinil?
 
There are numerous alpha an beta agonist and antagonist drugs, with verything levels of selectrivity and efficacies. Why are you interested in them in particular? Do you think them likely to 'fix' your mood in some fashion?

ebola
 
sekio said:
Try something more selective for a2 like yohimbe/yohimbine. Mirtazepine and mianserin are not selective and have activity at serotonin/histamine sites too. In fact they are not considered selective a2 antagonists but instead NaSSA (Noradrenergic and specific serotonergixc antidepressant) which are not going to help at all. H1 and serotonin antagonism doesn't increase activity levels; it decreases them.

Most a1 selective agonists are fairly unpleasant to work with (elevated heart rate, blood pressure, vasoconstriction) and are far more useful as decongestants or for controlling heart rate, but as stated before, try one or more of the following: synephrine, octopamine, ephedrine, phenylephrine, oxymetazoline, xylometazoline, adrafinil, or modafinil. Oxymetazoline/xylometazoline are commonly used as decongestant nose sprays.

Expect development of tolerance with all agents in this class of drugs. You're not going to be able to keep popping ephedrine indefinitely.

What kind of NRI did you try, and at what dose? Most NRI drugs take a long period of administration to show effects and almost all of them will make you feel like shit unles you dose it right.
Click to expand...
hi
i've tried drug called Edronax in 8mg/day, it's a selective NRI this med should give more energy but fir me it made much much much less energy and more depressed.
i also tried desipramine in up to 225mg/day, same issue like Edronax at every dose.
after that i tried to take desipramine 50mg per day while im using maoi, this time when i took the desipramine, i got boost of energy, it was clearly worked the way it should be but cause me a lot of side effects and i couldn't pass the 75mg desiprsmine, every time i did, it still took all energy out of me and made me depressed so i know i need something else instead of that, something with NE.
I think maybe i have deficiency NE that bringing into the Synaptic vesicles that cause too less NE but don't know hiw to solve it.
My depression is for nany years without stop it's not typical depression.
you have any suggestion medication for me?

Swerlz said:
Why do you think you need something to that effects NE?? you still haven't said why you need an a1 agonist that can cross the bbb... yes i know you said mood/energy, but to my knowledge.. NE doesn't solely control that.. I would think that would be a dopamine kind of deal


have you tried Modafinil?
Click to expand...
Reed my previous quote
and i didn't tried modafinil

ebola? said:
There are numerous alpha an beta agonist and antagonist drugs, with verything levels of selectrivity and efficacies. Why are you interested in them in particular? Do you think them likely to 'fix' your mood in some fashion?

ebola
Click to expand...
Hi
Read my first quote of this message (not thread)
 
sekio said:
Try something more selective for a2 like yohimbe/yohimbine [...] synephrine, octopamine, ephedrine, phenylephrine, oxymetazoline, xylometazoline, adrafinil, or modafinil.
Click to expand...

Those are a1 agonists (well except for yohimbine), go try them. Usually feeling "good" after MAOI usage involves a heightened concentration of dopamine, which "feels good" - maybe that's what was going on with desimpramine.
 
Thanks sekio, but if they addicting, i do not want to take them. Im looking for relief from my depression and my fatigue to trart in a new life for a long term.
Desipramine is NRI like, I've tried also zyban and it didn't helped
 
Are reboxetine analogues opioids at all? It reminds me vaguely of tramadol, but I don't think it itself has any such activity. What about it's analogues?
 
Ugh I would not tickle my adrenergic receptors personally! Perhaps only something like propanolol if there is real reason for it but not much else.
Modafinil does quite different things doesn't it? Like the orexin story could have something to it, frankly I don't know but modafinil is IMO a worthy compound.
 
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