Survival0200
Bluelighter
Soo, I'm taking 450 mg pregabalin a day. I was wondering would there be any point in taking gabapentin on top of that? Is there some kind of cross-tolerance?
Gabapentinoids Addicted to pregabalin. Does gabapentin even work?
- Thread starter Survival0200
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TheAcetylationGame
Bluelighter
There is definitely cross tolerance. Gabapentin is much weaker than pregabalin and also suffers from this annoying inverse dose-response curve where the more you take at one time - the less is actually absorbed into your body. This requires a method called “staggering” doses in order to get an actual sedative buzz (at least for someone with a tolerance).
I would take 300mgs every 15mins for 2 hours or so to get buzzed. Pregabalin doesn’t suffer from this and is much stronger IME. Much more like a ‘proper’ sedative I.e benzos.
However you certainly could switch to gabapentin to taper off and it would probably substitute for pregabalin if you ran out and all you had were gabapentin - just at much larger doses.
I was one of the lucky people who were incapable of developing a physical dependence on gabapentin. I took it for chronic tension headaches at 600mgs three times daily for 4 or 5 years and never had an issue stopping. I heard a lot of stories of people suffering from a pretty classic sedative withdrawal syndrome when they ran out or tried to stop.
I’ve only taken pregabalin a limited number of times, maybe ten or twenty times… my buddy had a script for it long after I came off gabapentin and he would throw me a couple trays every now and then and personally I think gabapentin would be a bit of a letdown coming from a background of pregabalin use. Pregabalin is a much more potent and enjoyable analogue of gabapentin IMO
I would take 300mgs every 15mins for 2 hours or so to get buzzed. Pregabalin doesn’t suffer from this and is much stronger IME. Much more like a ‘proper’ sedative I.e benzos.
However you certainly could switch to gabapentin to taper off and it would probably substitute for pregabalin if you ran out and all you had were gabapentin - just at much larger doses.
I was one of the lucky people who were incapable of developing a physical dependence on gabapentin. I took it for chronic tension headaches at 600mgs three times daily for 4 or 5 years and never had an issue stopping. I heard a lot of stories of people suffering from a pretty classic sedative withdrawal syndrome when they ran out or tried to stop.
I’ve only taken pregabalin a limited number of times, maybe ten or twenty times… my buddy had a script for it long after I came off gabapentin and he would throw me a couple trays every now and then and personally I think gabapentin would be a bit of a letdown coming from a background of pregabalin use. Pregabalin is a much more potent and enjoyable analogue of gabapentin IMO
to_oblivion
Greenlighter
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- Mar 19, 2025
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While pregab is slightly more enjoyable and "Pronounced" I would say high doses of gabapentin will always get the job done. You might have to stagger 800mg tabs 4x over 45min to get to 3200mg but its worth it. So worth it. You will feel much less weight on your shoulders managing your mental health because high doses of gab always hit the spot. You can keep going but I always wean down to 300mg x2 a day and then jump off it is really no big deal weaned down. However, beware of maintining high doses because you need to wean down before you come off.