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Stimulants Adderall Tolerance Theory. Opinions?

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piller97

Bluelighter
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Sep 23, 2013
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105
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Hello everyone, i have a theory about Adderall tolerance and I'm looking for input.
(i guess in theory this can apply to any drug, but I'm using Adderall)

It is my understanding that the general consensus on the development of Adderall tolerance is that after someone has ingested Adderall and its effects have begun taking place in the brain, the brain senses that something isn't normal and it adjusts itself(dopamine receptor down regulation, ect. ect.) to return itself to normal. Therefor resulting in an apparent desensitization and requiring larger doses to receive similar effects.

Considering this, would it not make sense that if someone was to use a substance with effects opposite to those of Adderall, that the brain would adjust itself once again, undoing the changes the brain made while it was on Adderall?

Of course the second substance couldn't just be any random depressant, it would have to be a substance that effects the same parts of the brain as Adderall or else the brain's resulting compensation would effect areas unrelated to Adderall and would have no effect on the first adjustments.
(or am i wrong?)


Though i haven't put much work into this,
I'd be really interested in hearing other peoples opinions on this as it seems to make some amount of sense.



I posted this to OD but I'm not to sure that it shouldn't be in Neuroscience and Pharmacology(if this is the case, id appreciate if a mod could move it)
 
A low does of an atypical antipsychotic that is a complete dopamine antagonist such as quetiapine (seroquel) wouldn't take a very high does especially for a first time or very occasional user (such as one who attempts to lower amphetamine tolerance)

50 mg of quetiapine will give you a long sleep of possibly 12+ hours. Wait a day for the drug to exit your system completely (I recommend a 24 hours after dosing) before dosing with Adderall again otherwise i'm afraid that any lasting effect from the quetiapine will lessen if not completely negate that of any amphetamines you administer to yourself regardless of ROA. Hope this helps if you need any extra info feel free to PM me.
 
You might as well just takes breaks off the Adderall because the antipsychotics essentially cause suffering and tend to linger in their effects. You would feel shitty enough being off the Adderall you don't need to enhance this with a neuroleptic.
 
Considering this, would it not make sense that if someone was to use a substance with effects opposite to those of Adderall, that the brain would adjust itself once again, undoing the changes the brain made while it was on Adderall?
Click to expand...

On paper you can present an argument for it, but in actual people nothing of the sort is observed.

Otherwise we would treat heroin dependency with naloxone and then people would magically be un-addicted and have no tolerance.
 
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