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  • BDD Moderators: Keif’ Richards | negrogesic

Adderall + Seroquel = New High?

Lightning-Nl

Lightning-Nl

Bluelighter
Joined
Nov 11, 2012
Messages
1,245
I saw this on a different forum around a week ago - but I was unsure if this was even real.

Some guy was saying that taking Adderall and Seroquel together causes some euphoric high or something - but based on these two drugs mechanism of action - I don't think this is correct.

Adderall and Seroquel's machanism of action are DIRECT OPPOSITES of each other. Adderall (racemic amphetamine) causes cells in the CNS to release Dopamine and Norepinephrine. It also inhibits their reputake in some special way. I know that Methylphenidate stops these two neurotransmitters reputake - but it does so by blocking the dopamine & norepinephrine transporter. From what I've read - Amphetamines don't block the dopamine transporter. But anyways I'm getting off topic. Seroquel is an anti-phsycotic that exerts its pharmacological action by antagonizing the big four (as I call it) - Dopamine, Serotonin, Epinephrine, and Norepinephrine. It is also a potent antihistamine. It seems to me that this would be counter-productive.

But I was curios. Has anyone tried these two together?
 
Sounds horrible. But drugs affect everyone differently so maybe that's why that guy said he liked it.

I wouldn't touch those two together with a ten foot pole.
 
Mixing these is not going to give you a "new high". Seroquel will counter-act the Adderall.

"Some guy" is just wasting drugs. The only time you should be mixing Adderall with Seroquel is if you're using the Seroquel to come down off the Adderall.
 
Noted.

That's what I thought. Mixing these two I was sure would be a total waste of both drugs. But that's why I asked.

Thanks everyone
 
I hate to bump an old thread, however, I just found out how Seroquel makes Adderall "better."

Around 4 hours ago, I was still feeling around 200MG's of Seroquel when I had taken it nearly 12 hours before then. So even though it wasn't anywhere near the same effect as when you first take it - it was still a little sedating and unpleasant. So I took 40MG's of Adderall to offset it.

For those that don't know - Quetiapine has the active metabolite, Norquetiapine. Norquetiapine's affinity for receptors and transporters is much lower than quetiapine, except Norepinephrine - which makes it a potent Norepinephrine reuptake inhibitor. From what I've read, Norquetiapine has the same potency as Methylphenidate when it comes to Norepinephrine.

So, when I took the Adderall, I felt extremely speedy and much more focused. However, when I got really hungry (which I did almost immediately after taking the Adderall) I got really light headed, shaky, nauseous, and I had to eat something. When I did, I felt much better, however, I still have a little bit of nausea.

I'm guessing the reason why this worked so well is due to the fact that all of the quetiapine had been metabolized so norquetiapine had it's huge effect on Norepinephrine.
 
seroquel will totally destroy the effects of adderall, i use trazadone, and seroquel as a last resort when i need to crash off of amphetamines when im out of opiates or benzos. sounds pretty stupid t othink both of them create some type of syngergy
 
That's what I thought and that IS what happens when you take Seroquel and it hasn't had time to metabolize. But I can tell you, my Adderall was much more powerful today and I'm absolutely sure that's what caused it.
 
Seroquel, I keep a couple around for the sleepless nights that come from time to time. Shit I take a quarter pill (from a 150) and I'm freeking out for the count. Like a deep ass sleep, that hangs over to the next day. Can't imagine enjoying a high on it. Although I love the way I feel after the fall.
 
olanzapine didn't ruin my meth highs even if it had only been 12 hours after taking the olanzapine that i then took the meth so i don't see why it would be much different than if you were to substitute meth with some other amphetamine
 
I'm guessing for most that the dopaminergic antagonism would outweigh any NRI properties in terms of euphoria. Dopamine is more reinforcing than norepinepherine, and agonists more than reuptake inhibitors, generally.
 
Ho-Chi-Minh said:
I'm guessing for most that the dopaminergic antagonism would outweigh any NRI properties in terms of euphoria. Dopamine is more reinforcing than norepinepherine, and agonists more than reuptake inhibitors, generally.
Click to expand...

While agree with all of that, quetiapine is fully metabolized into norquetiapine within 8 hours after ingestion, and norquetiapine around 4-5 hours later. The IC50's of Norquetiapine are all microscopic, except for it's affinity to Norepinephrine would is quite massive.
 
I love the mix of pseudoscience and ill advised drug experimentation brought on by curiosity from an internet forum post. 8)

be safe dude.
you had a tiny bit of Seroquel in your system and you say you "got really light headed, shaky, nauseous, and I had to eat something. When I did, I felt much better, however, I still have a little bit of nausea."

now you are justifying this has as being some "new high" and talking about mechanism of action.

be safe and use common sense. good luck
 
^Welcome to bluelight.

You haven't been here too long. I can tell you that the combination of adderall and seroquel is a very common one as far as prescriptions go, especially in the united states, and that there are frequently threads that are far more irrational than this one. Most of the time ops don't have the decency to research a drug or combination without asking about it. Clearly SwampFox deserves his thread.

Its important to talk about the mechanism of action so that dangers can be averted.

That said I've researched amphetamines mechanism of action fairly extensively and can state that they don't have entirely opposite mechanisms of action, though they cancel each other out to an extent; I doubt two such psychiatric drugs completely stop each others action. To the best of my knowledge, amphetamine inhibits re-uptake and acts as a substrate for DAT, then once in the cytoplasm, for VMAT2, causing transport into the vesicle and (the confusing term) "reverse transport"; it also does a bunch of other funky things, but it has a similar action on norepinepherine, and at high doses, serotonin.
 
Ho-Chi-Minh said:
^Welcome to bluelight.

You haven't been here too long. I can tell you that the combination of adderall and seroquel is a very common one as far as prescriptions go, especially in the united states, and that there are frequently threads that are far more irrational than this one.
Click to expand...

Not to be taken at the same time... Seroquel is used during the comedowns... Blood pressure will be out of whack mixing these two on a regular basis at the same time.
 
Corazon said:
I love the mix of pseudoscience and ill advised drug experimentation brought on by curiosity from an internet forum post. 8)

be safe dude.
you had a tiny bit of Seroquel in your system and you say you "got really light headed, shaky, nauseous, and I had to eat something. When I did, I felt much better, however, I still have a little bit of nausea."

now you are justifying this has as being some "new high" and talking about mechanism of action.

be safe and use common sense. good luck
Click to expand...

I actually hate the effects of them combined. It was way too "norepinephrinergic." I felt horribly speedy, my heart was racing, and therefore - my anxiety was increased ten fold. The point of this post was to outline why some may consider this "a new high" by basing this on science. We determined this was ludacris (read previous posts), but then I had come to learn that when it has mostly worn off, but still slightly in your system, the Norquetiapine causes extreme potentiation of the adrenergic system, which I would have never realized had I stumbled upon it.

Ho-Chi-Minh said:
^Welcome to bluelight.

You haven't been here too long. I can tell you that the combination of adderall and seroquel is a very common one as far as prescriptions go, especially in the united states, and that there are frequently threads that are far more irrational than this one. Most of the time ops don't have the decency to research a drug or combination without asking about it. Clearly SwampFox deserves his thread.

Its important to talk about the mechanism of action so that dangers can be averted.

That said I've researched amphetamines mechanism of action fairly extensively and can state that they don't have entirely opposite mechanisms of action, though they cancel each other out to an extent; I doubt two such psychiatric drugs completely stop each others action. To the best of my knowledge, amphetamine inhibits re-uptake and acts as a substrate for DAT, then once in the cytoplasm, for VMAT2, causing transport into the vesicle and (the confusing term) "reverse transport"; it also does a bunch of other funky things, but it has a similar action on norepinepherine, and at high doses, serotonin.
Click to expand...

Well said. Not many people actually do the extended research these days and by doing so - it adds at least another half-an-hour to the amount of time it takes to make a thread. Therefore I really appreciate the compliment as well as your candor and "pat on the back." :)

I do have to say though, I know Seroquel and Adderall aren't "direct opposites." However, they're pretty damn close. I just decided to sum it up that way, rather than go through the complicated pharmacodynamics of both drugs and point out where they're different. You summed it up pretty well though. I might use that as a quote some day lol.
 
Seroquel is going to almost cancel out all of adderalls effects.

It's as simply as that. It will in no way contribute to the high from adderall, and should only be taken on the comedown. I realize the original OP is old, but no one seems to be straight answering the question.
 
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