Adderall + Seroquel = New High?

[pasha]

In some cases and anecdotes, even when the combination was prescribed, dystonia, hypertensive crises, psychosis, and other adverse effects presented themselves. When the amphetamine dose is anonymous, the risk of adverse effects becomes much bigger.

For one thing, anti-psychotics don't address the cardiac effects of amphetamines, for another, hyper/hypodopaminergic states have been noted when these two drugs are taken concurrently since some receptors are shut and others are open leaving those open vulnerable to extreme dopaminergic fluctuations (complex dopamine theory). When an underlying psychotic disorder exists, this can exacerbate it, and if it doesn't, it may well serve to trigger it

There's been many instances where people asked about practicing this combination as prescribed and I've had no objection, as a matter of fact, aripiprazole has shown great promise with amphetamines since it's a partial dopamine agonist. I must reiterate though, the risk of facing issues with this combination can be mitigated when the drugs are prescribed, but if not, it can be a significant risk.

Several years ago I read that quetiapine enhances amphetamine effects when ingested prior to a stimulant dose through its adrenergic blocker action. I'm unsure how much validity there is to that.

 

[red_bandit]

Seroquel is a different drug at different doses!

Keep in mind that Seroquel's affinity for different type of receptors is highly dose-dependent. At low doses, it acts mainly as an anti-histamine with very little affinity for DA receptors, which dominates at higher concentrations and is responsible for its anti-psychotic effects. Seroquel is increasingly being prescribed off-label at low doses (like < 200mg) as a hypnotic because it's thought to have less potential for tolerance and dependency. AstraZeneca aggressively marketed it for this purpose until the FDA slapped a huge fine on them. Regardless, it's still very popular for treating insomnia, despite having effects on NE at these low doses as well. Under 200mg IR, Seroquel is really nothing more than glorified Benedryl.

The anti-dopaminergic/anti-psychotic effects usually require doses much greater than 200mg (when I was taking it for bipolar mania, I was on 600mg of the XR/day). I would expect that the effects of taking Seroquel + Adderall wouldn't cancel out unless you're taking a shitload of Seroquel. With lower doses, the sleep-promoting anti-histamine effects might be overcome by the stim. Furthermore, an increase in jitteriness/NE side effects makes total sense since low concentrations of Seroquel still effect NE in a big way.

Here is a somewhat humorous blog piece explaining Seroquel's dose-dependent variability in receptor affinity/behavioral effects.

Just as an aside, after a long while on 600mg/day, I developed some serious Parkinsonian side effects. The tremor was so bad that I couldn't walk. Thankfully it was reversible extrapyramidal issues - and not permanent tardive dyskinesia - that went away a month or so after I stopped taking the Seroquel. Scary, scary shit.

Namaste

 

[Pillseeker]

Sounds horrible. But drugs affect everyone differently so maybe that's why that guy said he liked it.

I wouldn't touch those two together with a ten foot pole.

LOGan1314 Pretty much hit the nail on the head. I personally love Adderall. It's definitely one of my favorites. The idea of combining Seroquel and Adderall sounds terrible. I have taken both recreationaly before. (up to 600mgs of Seroquel in one dose; which ended very badly might I add: and up to 300ish mgs of Adderall over a 72hr period.) Combining these two drugs likely would destroy the 'highs' you would achieve from either. Seroquel is not a recreationaly used narcotic by any means. I don't even think it is a controlled substance. My advice to you is; take your Adderall and race around on that until you have nearly come down all the way. At that point proceed to take your Seroquel, lay down, and get some rest.

[merge]

The anti-dopaminergic/anti-psychotic effects usually require doses much greater than 200mg (when I was taking it for bipolar mania, I was on 600mg of the XR/day). I would expect that the effects of taking Seroquel + Adderall wouldn't cancel out unless you're taking a shitload of Seroquel. With lower doses, the sleep-promoting anti-histamine effects might be overcome by the stim. Furthermore, an increase in jitteriness/NE side effects makes total sense since low concentrations of Seroquel still effect NE in a big way.

I failed to read this before my last post. As red_bandit stated that is also a significant variable in the 'Seroquel equation.' In lower doses Seroquel has hypnotic effects, in higher doses it is used for anti-dopaminergic/anti-psychotic purposes. Adding Adderall to that equation you would definitely want to keep that significant factor in mind.

 

[blight12]

This thread has some interesting info.

Having used high dose meth with Seroquel many times (The Seroquel at 150mg to kill the meth) I have noticed many strange effects that seem to affirm as well contradict some understandings and theory.

I will list a few that seem related to some info here:

1. Seroquel after meth (before meth wears off and before the comedown begins) is incredibly powerful in terms that I had to half my normal sleeping dose from 300mg to 150mg when using on meth to reduce some of the powerful effects.

If it kicks in while you are up or walking, it seems to drop BP incredibly. I would be unable to walk for more then 30 seconds without the intense light headed bright vision blacking out effect of fainting kicking in. Zero energy and heavy breathing etc.

I ascribed this effect to the BP effects and other on a system that has not has any sleep or sufficient nutrition for days.

2. When taking and lying down ready to sleep while still on the meth, its possible to pass out instantly. The sensation is like you are still high in some way except you are really tired. Is if its not really killing the stim but modifying part of the stim to allow sleep.

3. NEVER fuking take it when coming down. Seroquel is the worst thing to experience when you have anxiety. Taken within a comedown or panick attack initiates a wierd effect where the comedown anxiety remains and gets worse but somehow the physical (not mental) stimulation goes away allowing unconciousness. The huge problem with this is that you physically feel like you are falling asleep and unconscious but mentally you are still anxious and very stimulated.

The end result is that you fight the falling unconscious effect tooth and nail because it feels like you are dying due to the inability to stay awake while your mind and paranoia are alive and well. You are convinced if you fall unconscious you are dead. This sensation of falling asleep with an active stimulated mind feels is utterly unnatural and terrifying to the core.

My conclusion is that it effects some of the stimulant action, dopamine and norepinephrine but not all of it resulting in a version of the results you want by falling asleep but some other related wierdness and bad shit remains. Sort of like sleeping through the comedown which still occurs in the background.

My family has seen my flapping and jerking around in my bed like having a seizure while sleeping peacefully (in my mind and perspective) after taking seroquel, but I do know that the effects of passing out on substances like alcohol during the comedown are far far worse then those after taking Seroquel.

 

[Venrak]

Listen to Chrom.

Anti-psychotics should not be taken when strongly under the effects of amphetamine, or vice-versa.

 

[Seth.Lee713]

Just a heads up to anyone thinking of trying this combo of adderall and seroquel - be very careful! My sister OD'd on that mix but luckily we got her to the ER in time. Not sure what dose she took but I would be very wary of trying this particular mix. Just my 2 cents.

 

[_DankOpiAmp_]

Didn't they pay a doctor to lie and say snorting seroquel is like cocaine and that is why it is the only neuroleptic that has street value? It is just more bullshit. Anyone who tries this should be euthanized. A pharmaceutical representative probably posted it. Seroquel is not recreational in any way under any circumstances, fucking retards, we need to start up the crematorium.

Also, norepinephrine has little, if any, recreational effect. It make up a lot of the side-effect component of stimulants etc. A nauseated hypertensive state is not fun nor is it a "high". Someone needs to find that poster in the other forum's IP address/location then hire a contract rapist to show him why encouraging dangerous and pointless drug combinations is wrong, with his cock.

 

[opiatekrzy]

Seroquel has jailhouse value and in prison upstate don't forget the rehabs, on the street it's poop, last resort to kill a crash..or to sleep

 

[Lightning-Nl]

No question Seroquel is utter crap. I hated it while I was on it. Fortunately, I'm no longer condemned to a life full of antipsychotic drugs.

One might consider Benzos just as bad, or maybe even worse than antipsychotics - but at least Ativan allows me to keep some shred of my sanity...

 

[Brandon miller]

Is there another similar conversation on a newer thread, sorry to post on an outdated thread but I need to point out something pretty interesting, alcohol and adderall are opposites also, but a lot of people like mixing them, what if it's the same situation with the seroquel and adderall?

 

[Brandon miller]

If theirs people here that closes outdated threads on this site please forgive me for making you have to do that.

 

[mygreenbic]

This thread has some interesting info.

Having used high dose meth with Seroquel many times (The Seroquel at 150mg to kill the meth) I have noticed many strange effects that seem to affirm as well contradict some understandings and theory.

I will list a few that seem related to some info here:

1. Seroquel after meth (before meth wears off and before the comedown begins) is incredibly powerful in terms that I had to half my normal sleeping dose from 300mg to 150mg when using on meth to reduce some of the powerful effects.

If it kicks in while you are up or walking, it seems to drop BP incredibly. I would be unable to walk for more then 30 seconds without the intense light headed bright vision blacking out effect of fainting kicking in. Zero energy and heavy breathing etc.

I ascribed this effect to the BP effects and other on a system that has not has any sleep or sufficient nutrition for days.

2. When taking and lying down ready to sleep while still on the meth, its possible to pass out instantly. The sensation is like you are still high in some way except you are really tired. Is if its not really killing the stim but modifying part of the stim to allow sleep.

3. NEVER fuking take it when coming down. Seroquel is the worst thing to experience when you have anxiety. Taken within a comedown or panick attack initiates a wierd effect where the comedown anxiety remains and gets worse but somehow the physical (not mental) stimulation goes away allowing unconciousness. The huge problem with this is that you physically feel like you are falling asleep and unconscious but mentally you are still anxious and very stimulated.

The end result is that you fight the falling unconscious effect tooth and nail because it feels like you are dying due to the inability to stay awake while your mind and paranoia are alive and well. You are convinced if you fall unconscious you are dead. This sensation of falling asleep with an active stimulated mind feels is utterly unnatural and terrifying to the core.

My conclusion is that it effects some of the stimulant action, dopamine and norepinephrine but not all of it resulting in a version of the results you want by falling asleep but some other related wierdness and bad shit remains. Sort of like sleeping through the comedown which still occurs in the background.

My family has seen my flapping and jerking around in my bed like having a seizure while sleeping peacefully (in my mind and perspective) after taking seroquel, but I do know that the effects of passing out on substances like alcohol during the comedown are far far worse then those after taking Seroquel.

Isn't it possible that the dizzy feeling is from the drop in blood sugar most likely caused by the seroquel and the poor diet caused by meth/amphetamine use?