Nope, i took a 5 yr old addy 12 hrs ago and a 1 yr old one, same exact effects, ive been on 3 addy benders this last 2 weeks, being up for 4-5 days at a time and no harmful effects.
ALSO THIS IS NOT FOR OTHERS TO ASSUME THEY CAN HANDLE - however to note, i used very high doses aswell, exceeding 300-400mg+ per day and i still again, didn't have any harmful effects.