Adderall and Oxymorphone Safe To Mix ?

[kokaino]

pharm. speedballs aren't that good, and imo they waste the opiates because the adderall will overpower the opiates, or atleast for me and i didn't get much from adding 30mg hydrocodone 2mg klonopin 30mg oxycodone and 20mg adderall...i only felt the speedy effects and never felt any euphoria...i would dose the addie wait 8-12hours and then dose the oxymorphone...

An opiate mixed with Adderall is not a speedball, neither is any opiate mixed with cocaine a speedball.

A true speedball is cocaine mixed with morphine or it's salt, morphine diacetate (heroin). The original speedball was morphine sulfate and cocaine.

 

[zyNc973]

pharm. speedballs aren't that good, and imo they waste the opiates because the adderall will overpower the opiates, or atleast for me and i didn't get much from adding 30mg hydrocodone 2mg klonopin 30mg oxycodone and 20mg adderall...i only felt the speedy effects and never felt any euphoria...i would dose the addie wait 8-12hours and then dose the oxymorphone...

for me it wouldnt be the same. according to your theory, and then using my opinion, adderall would be the perfect drug to incorporate with the morphone. that is because i feel adderall is the weakest IR prescribtion amph. i would feel strictly downer effects from that combo, and minimal to any stimulation. 20mg adderall is way too weak a dose to overpower the other downers. some dex/meth along with some oxymorphone/heroin, thats fucking powerful. you will feel the effects of both, id imagine it would be one hell of a speedball.

 

[NeighborhoodThreat]

You're not that far off....

[PubMed] Ephedrine enhances analgesic effect of morphine. An article about using the stimulant ephedrine with morphine for post-operative analgesia.

Ephedrine is even weaker than mixed amphetamine salts (Adderall), and in the article linked to above, it shows that mixing the two actually results in increased analgesia with a lowered morphine dose and less side effects (partially because the ephedrine's stimulant effects counteract the sedating effects of the morphine).

Edit: After some more PubMed browsing, I found this article as well, which I think you all will find interesting.

[PubMed] The use of methylphenidate in patients with incident cancer pain receiving regular opiates. A preliminary report.

In this open, uncontrolled trial, 15 patients with severe incident cancer pain receiving regular opiates were administered 10 mg oral methylphenidate (MP) at 08.00 h and 15 mg at 12.00 h in order to antagonize opiate-induced sedation. The daily dose of opiate was increased by 30% 24 h after starting MP, followed by a 10% increase twice a day until maximal tolerated dose. In 14 evaluable patients, pain (VAS 0-100 mm), sedation (VAS), and mean equivalent daily dose (MEDD) of morphine were 55 +/- 17, 65 +/- 18 and 248 +/- 150 48 h before MP, versus 38 +/- 12 (P less than 0.01), 42 +/- 12 (P less than 0.01), and 405 +/- 130 (P less than 0.01) 48 h after MP, respectively. After 48 h of treatment, 12 of 14 patients felt better on MP, 2 of 12 patients felt no difference, and no patients felt worse (P less than 0.05). We conclude that the addition of MP allowed for an increase in the MEDD of morphine and increased pain control. Controlled double-blind trials should be performed.

While this article deals with methylphenidate, not amphetamine, its still interesting because it showed that, in a medical setting, patients were able to have their opiate dose increased when they had been administered methylphenidate, allowing for their pain to be better treated.

 

[laCster]

They may not be "that good" compared to the true speedball, but they're certainly much safer, as kokaino described in detail above. ^

It's even more common practice for people to use opiates to come down off uppers.

As far as 30mg hydrocodone, 30mg oxycodone, 2mg clonazepam and 20mg mixed amphetamine salts (Adderall) goes, I imagine you've got a tolerance for the opiates?

Also, mixing oxycodone, which is considered by many to be one of the more stimulating opiates with a stimulant will most likely enhance the stimulating effects.

yup and hardly any adderall tolerance : / i don't remember how much klonopin i downed that day.. i just kept chompin away because i couldnt stop grinding my teeth, anxiety, and all around bad feeling...i just wanted to nod out but never did and i dont remember the day

 

[NeighborhoodThreat]

^Teeth grinding is a common issue with Adderall (and other amphetamines, but it seems to be more common with Adderall - possibly because the Adderall formulation contains dextroamphetamine and levoamphetamine, perhaps the levoamphetamine is to blame.)

Benzos can certainly help with this issue, but it sounds like you took a bit too much Adderall either way.

Using magnesium supplements regularly can help with jaw clenching/teeth grinding and muscle tension that comes with high doses of amphetamines.

 

[K'd-OUT-in-AZ]

I've never mixed Adderall with oxymorphone orally, but rather IV, and I enjoyed the combination. From what I remember it made my head tingle. Is it safe? It may be dangerous but only to a certain extent & certain people. Someone healthy like me who suffers no heart problems can handle it safely. I've done it plenty of times, in fact I've been prescribed an opiate with an amphetamine for maybe 5 or more years.

 

[kokaino]

Dextroamphetamine is not all that much better when it comes to the teeth grinding, but I agree Adderall is probably worse due to levoamphetamine's assault on the autonomic nervous system.

 

[K'd-OUT-in-AZ]

You're not that far off....

[PubMed] Ephedrine enhances analgesic effect of morphine. An article about using the stimulant ephedrine with morphine for post-operative analgesia.

Ephedrine is even weaker than mixed amphetamine salts (Adderall), and in the article linked to above, it shows that mixing the two actually results in increased analgesia with a lowered morphine dose and less side effects (partially because the ephedrine's stimulant effects counteract the sedating effects of the morphine).

Edit: After some more PubMed browsing, I found this article as well, which I think you all will find interesting.

[PubMed] The use of methylphenidate in patients with incident cancer pain receiving regular opiates. A preliminary report.



While this article deals with methylphenidate, not amphetamine, its still interesting because it showed that, in a medical setting, patients were able to have their opiate dose increased when they had been administered methylphenidate, allowing for their pain to be better treated.

Well I don't know about ephedrine or methylphenidate but amphetamine is an analgesic which not many people know.

 

[NeighborhoodThreat]

^I didn't know this either, I can certainly see how stimulants (ephedrine and amphetamine are very similar in their method of action, methylphenidate is a bit different, as I'm sure you know ) enhance the painkilling action of opiates. Ephedrine is a dirty drug compared to methylphenidate or amphetamine, but it is weaker and has a less harsh comedown, which may be why it was chosen for that study. I'm going to do some more searching on PubMed later on in regards to medical studies/case studies as far as mixing pharmaceutical stimulants and opioids/opiates go.

As far as Adderall vs. Dexedrine goes, I've also noticed that Adderall causes worse muscle tension in general than Dexedrine does, not just tension in the jaw.

 

[kokaino]

As far as Adderall vs. Dexedrine goes, I've also noticed that Adderall causes worse muscle tension in general than Dexedrine does, not just tension in the jaw.

Yeah I agree. That's because of levoamphetamine's massive assault on the autonomic nervous system.

 

[NeighborhoodThreat]

AFAIK, the inclusion of levoamphetamine in the Adderall preparation is for nothing more than patent/drug manufacturing rights, yes?

I don't see how levoamphetamine could play a role in helping ADD/ADHD. Dextroamphetamine certainly helps, but it sounds like the pharm company (Shire Pharmaceuticals IIRC) that initially marketed Adderall/mixed amphetamine salts is just wasting part of their formulation on an isomer that does more harm than good.

 

[kokaino]

Well levoamphetamine not completely devoid of any psychological effects, it does have pscyhostimulant effects like the dextrorotatory stereoisomer of the amphetamine molecule, but just much weaker.

Amphetamine is a racemic mixture. Methadone too is a racemic mixture. A lot of drugs are.

 

[NeighborhoodThreat]

Makes sense. I guess I'm just wondering why they used the racemic mixture when they could have used the dextro-only version (dextroamphetamine).

 

[laCster]

They may not be "that good" compared to the true speedball, but they're certainly much safer, as kokaino described in detail above. ^

It's even more common practice for people to use opiates to come down off uppers.

As far as 30mg hydrocodone, 30mg oxycodone, 2mg clonazepam and 20mg mixed amphetamine salts (Adderall) goes, I imagine you've got a tolerance for the opiates?

Also, mixing oxycodone, which is considered by many to be one of the more stimulating opiates with a stimulant will most likely enhance the stimulating effects.

yah i kno it isnt a speed ball but i didnt mean the actually one...i sort of use it as a term that invludes opiates with stimulants

amd i agree, i potenitated 30mg roxi (oral wwith tagamet, grapefruit juice + tonic water+ a fatty meal + 2mg klonopin + 150mg lyrica + diphenhydramine + a couple bowls of this good purp and oher siiit and i am stimulated like fuck but the part where i was like "oher siiit" i started to nod and then faveplatned into my keyboard lmfao nut really idk i just dont tlike the adderall that much.. uavtually its great fir oarttie sandss

 

[NeighborhoodThreat]

Clearly.

Sounds like you're nodded out. Just for the record, we don't allow real-time trip reports (even though I doubt you intended that to be one).