Perhaps look into kava kava....it is something I take on a near daily basis, and I suffer from intense anxiety all the time, not just whilst tripping. Kava supposedly mixes extremely well with psychedelics. I know from experience it has very nice synergies with weed and also caffeine.
Imagine it like weed, but different. A peaceful, comforting, relaxing, cozy little bubble. Add that to anything and it's better. Kava is especially nice because it relaxes you physically but your mental function remains lucid, whereas weed can cloud a trip. I use the one by Herb Pharm, it's very potent.