Opioids Achieving the same high from oral Opana ER as insufflated (dosage question)

[Harrisment]

I have an adequate supply of Opana ER 20 mg's that I'm trying to determine the best way to use. For a couple weeks I have been splitting them in half, and taking 10 mg insufflated (once a day). This does the trick, but I'm getting tired of this route because it is killing my sinuses, and there is also the lung damage concern. Since I have plenty, I'm wondering how I could achieve a similar buzz taking them orally? I realize the BA is much lower orally, so I'd need to take more than 10 mg. Would 30 mg chewed and swallowed be about an equal dosage?

 

[The Rock Monster]

Hmm. Ive never used Opana.. i know you can smoke subutex off foil, that works nicely.. maybe you could take them sublingually..that seems to be more effective than eating pills

 

[RoxisLover]

I believe you would need to multipu the snorted dose by 4 and that would be equivalent from what I've read. Since oral BA is 10% and Snorted is more around 40 - 50%.

 

[amapola]

Oxymorphone nasal bioavailabilty [43%] orals low 10-20% Rectal ~10%
Bioavailability/Half-life MEGA Thread

You can improve the oral ROA by taking it with a fatty meal. For ER peak plasma level doubled and AUC slightly improved. link

As these are extended release drugs and a new method of administration, quadrupling your usual dose your first time would be quite foolhardy and putting a helluva lot of faith in average values.

 

[f13nd]

intranasal is a must, increase BA to 50%, perhaps try making a nasal mist spray to mix with the opana OR just spray after u use it so u clean ur nostrils. Fatty Meal and supposedly some alcohol both help the BA. Good luck. oh and if u dont sniff them...jeez...id say uh..dont waste em just uh...find some way you could get something strong that u can sniff if its the ER thats the prob or just a high oral BA

 

[opiateking]

The oral ba is 10% give or take, and IN ba is about 30% give or take so u do the math

 

[Coolwhip]

Don't eat them, you are never going to get as much out of eating them as intranasal.

You've got two options I think. Toss the entire pill into some water(or a couple pills), uncrushed, wait 24 hours. The oxym should have moved into the water without gelling up. Toss the water into a nasal sprayer. Basically just prepare the opana like you were going to IV it, but put it into a nasal sprayer instead. I have found most the sprayers spray about .1ml of water per spray, but you should calibrate it first with plain water.

Or

crush the pills, gel up the water, and toss the gel into a nasal sprayer. I have never done this, but the nasal sprayers come filled with goop already, maybe they could spray out the opana gel? I've never actually watched one gel up the water, so I don't know how thick it is.