Acetaminophen altering effects of peptides

[JohnBoy2000]

I excessively dosed 4 pills (2 grams) of paracetamol, typically daily, for about 4 years.

Some days maybe only 2 pills (1 gram).

I've stopped now.

But over that time, I noticed I develop intolerances to other chemicals such as Vitamin A in topical formulation (called tretinoin or differin, retinoids), and melanotan 2 (tanning peptide).

Curious whether one could be related to the other.

Could excess acetaminophen consumption cause intolerance to the latter two chemicals?

Maybe bring out a hypersensitive response to them (that wasn't there earlier, prior to commencing the acetaminophen use?

I also developed low level tinnitus, which may be linked to excess acetaminophen use also.

 

[JohnBoy2000]

Alcohol: How It Can Affect Your Body

Alcohol affects the body and brain by interfering with cognitive function, mood, balance, sleep, digestion, and the function of the liver, kidneys, heart, and pancreas. Alcohol affects hormones, hearing, immune function, body temperature, and bone and muscle strength.

www.medicinenet.com

Some allusions to inhibitions of metabolic pathways via chronic acetaminophen use?

 

[PtahTek]

Oh yes I quit taking 5mg oxy or hydro as I od-ed on the Tylenol wasn't pretty in the least... like 2-3 days sick. Wasn't enough opioid but too much garbage. Took me twice to learn my lessen.
Won't touch the stuff now.
I don't mess with a lot of stuff these days for one reason or another.
Please be safe with all thing substance.

 

[klfiend]

Acetaminophen can really screw your liver. I recommend getting baseline liver function tested. Liver damage from Acetaminophen can interfere with drug metabolism.