Aceburic acid

[Haoma]

Does anyone have any info on this chem? Also does anyone know if the acetyl is cleaved during metabolism like is the case in acetyl tryptamines? It seems like the most logical GHB RC next to GBL.

If one were to change the oxygen to a nitrogen would this be able to cross the BBB and transport GABA into the brain? I don't know if it would metabolize the same though.

 

[sekio]

4-acetoxy-GHB, it should be metabolised pretty rapidly by esterases into GHB.

Essentially a GHB prodrug like GBL, or 14,B.

Changing the carboxylate to an amide might make it metabolise into GABA instead, but GABA prodrugs are a lot less recreational than GHB.

 

[mad_scientist]

Yeah just a pro-drug for GHB, unfortunately unlike GBL, aceburic acid is already illegal anywhere that GHB is illegal, as an ester of GHB.

 

[Mr Chemist]

While we're talking about GHB derivatives, anyone know anything about the ethyl ester? more lipophilic than ghb and it will metabolize into booze to provide a nice little accompanying treat.

 

[alkap555]

Would still be illegal but probably work just the same, maybe higher BBB penetration but according to the following study, GHB undergoes rapid high volume carrier-mediated transport through the BBB, possibly via the monocarboxylate transporter...if this is the rate limiting step in CNS uptake, who is to say that these modifications won't decrease carrier-mediated transport by altering the ligand-protein interactions--after all you would be effectively protecting the carboxylate moiety at least until it is hydrolyzed.

http://www.ncbi.nlm.nih.gov/pubmed/15173314