Ethnobotanicals According to many studies, ginseng appears to 'antagonize' a few well known recreational drugs

[daturetard]

So i was reading up on some teas i bought today, including american ginseng. In the wiki page for Pseudoginsenoside-F11 (found in American, but not Asian ginseng) claims that it antagonizes methamphetamine, scopolomine, and morphine. All drugs that are known by the average (if at all, for scop) person for their horrible effects on the brain. So it sounds to me like it most likely blunts negative (and probably positive) effects of the drugs, which will change the experience as a whole obviosly, and would be likely less intense, resulting in it being refered to as antagonistic.
I'm focusing on morphine here, but mostly, I don't believe that it could possibly be actual antagonists at all of these receptor sites. From what I've read in these sources they list for morphine, it doesn't seem like there's any evidence of actual opioid antagonism, however, it can reduce behavioral changes and memory impairment. Half of me says this is good, but half of me also likes memory impairment
One of them also mentions it significantly decreasing analgesia. One other thing to mention is the insane doses they give to rats of these pure, single plant extracted compounds. Like 5mg/kg, when a 2 gram teabag of ginseng is ~10-20mg/kg of untreated herb.

https://www.sciencedirect.com/science/article/abs/pii/S0091305707000822?via%3Dihub

Antagonistic Effect of Pseudoginsenoside-F11 on the Behavioral Actions of Morphine in Mice

LI, Z., C. F. WU, G. PEI, Y. Y. GUO AND X. LI. Antagonistic effect of pseudoginsenoside-F11 on the behavioral actions of morphine in mice. PHARMACOL B…

www.sciencedirect.com

 

[Esperighanto]

The glutamate reduction may indicate a dissociative effect, I can't find much record of folk use of this plant for psychoactive properties and the compound itself is WAY too complicated to synthesize, but I'd love to know what a trip report would sound like from pseudoginsenoside-F11.

 

[Leprechaun]

Ginseng almost completely changes the effects profile of amphetamine class drugs and can result in physical discomfort and severe anxiety. It has also been known to cause serotonin syndrome in some situations.

So do be careful!

 

[Halif2]

Ginseng almost completely changes the effects profile of amphetamine class drugs and can result in physical discomfort and severe anxiety. It has also been known to cause serotonin syndrome in some situations.

I had no idea about this, and I do drink ginseng tea sometimes - Korean Ginseng. Is this negative effect of profile found in all types of ginseng? Or just American ginseng as mentioned by OP?