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Accidental iv phosphate-buffered saline admin

hfrs

Bluelighter
Joined
Aug 18, 2006
Messages
1,286
Location
MD
This is more for informational purposes (if anyone were to do this in the future). It was NOT done intentionally and is not recommended!

The person who did this normally makes their own saline starting with 500 ml bottles of sterile distilled water, adding 4.5 NaCl (lab grade). By mistake a 10x bottle of PBS (phosphate buffered saline - Ca2+/Mg2+ free) was grabbed (identical bottles - missed the label) and the sodium was added to this. This stuff should have been diluted 10-fold before even being used - and it is not made for injection purposes. I don't even want to know what the osmolarity and tonicity of this solution ended up being, but it couldn't have been good!

A total estimated volume of 20 ml was injected intravenously. Immediately after the shot, actually during administration a sharp headache started. This was followed by nausea and general malaise over the next 20 hours. The person survived this stupid incident with no known permanent damage, but it is not recommended as a substance for iv use!
 
Why is this person making their own saline?

It's cheap, readily available, and you know it'll be sterile.

Interesting read though, now we know what happens when it's too concentrated.
 
Because it takes about 30 seconds and they use quite a bit of it!~ It was also phosphate buffered, so it had a lot of Na and K phosphate in there as well. I'm really surprised there wasn't a more severe reaction, I would have thought it would have been a lot worse than it was.
 
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