Misc Abuse potential of little known seizure medications?

[Borax]

First of all I'm very curious about Felbamate and Cenobamate, being carbomate derivatives I wonder if they may have similar effects to mebrobamate or soma, and what metabolites they may have. They are more selective on the agonization of the Gaba A receptor so I'm not quite sure.

Next interesting compound would be Parempanel, which is controlled and hits the AMPA receptor as an antagonist, targeting glutamate in a similar way to NMDA antagonist, Parempanel (or Fycompa) showed abuse potential VS placebo and the claim has been made that it has dissociative effects akin to ketamine.... I'm not all that convinced as Topamax is also an AMPA antagonist and is the opposite of a good time. The claims haven't been substantiated so let's leave it up for debate.

Also there is fenfluramine which is an amphetamine like compound alleged to have stimulant like effects, vastly increasing serotonin and to a lesser degree dopamine.

Ganaxalone, A neuroactive steroid GABAA receptor positive modulator prescribed for seizures associated with CDKL5 deficiency disorder. It is scheduled.

And lastly, lacosamide, which for whatever reason is controlled as well, from my recollection it may target 5ht2 or 5ht1 receptors giving it potential psychedelic activity.

Something else to note is I have extensively experimented with primidone, a pro drug to phenobarbital and find it to have absolutely no abuse potential but I would like to hear how others have found it.

I would really like to hear the 2 cents of some people who have experimented with these meds for recreational purposes.

-Borax

 

[Borax]

Bump ^

 

[Allylbenzene]

Ganaxalone, A neuroactive steroid GABAA receptor positive modulator prescribed for seizures associated with CDKL5 deficiency disorder. It is scheduled.

The closest I have is using an analog of what Ganaxalone is based on.

Ganaxolone, a synthetic analogue of allopregnanolone, is an endogenous modulator of GABA in the CNS with no appreciable affinity for oestrogen or progesterone receptors.

Biosynthesis of allopregnanolone:

Regular allopregnanolone is used for PPD:

Allopregnanolone itself shows myriad therapeutic benefits:

I use pregnenolone specifically (not allopregnanolone) which is sold OTC and has myriad therapeutic value. For context:

As an aside... I find all the anti-epileptics understandable (especially Ganaxolone) but it's strange that there are no treatments which address the causative dynamic of excessive excitatory signalling. This seems like an obvious strategy to resolve the issue, especially since the body is perfectly capable of making potent anti-epileptics (GABAergics, anti-glucocorticoids) as depicted above.

// also, are you the same borax from DrugNerds on reddit?

 

[Borax]

The closest I have is using an analog of what Ganaxalone is based on.

Biosynthesis of allopregnanolone:

Regular allopregnanolone is used for PPD:

Allopregnanolone itself shows myriad therapeutic benefits:

I use pregnenolone specifically (not allopregnanolone) which is sold OTC and has myriad therapeutic value. For context:

As an aside... I find all the anti-epileptics understandable (especially Ganaxolone) but it's strange that there are no treatments which address the causative dynamic of excessive excitatory signalling. This seems like an obvious strategy to resolve the issue, especially since the body is perfectly capable of making potent anti-epileptics (GABAergics, anti-glucocorticoids) as depicted above.

// also, are you the same borax from DrugNerds on reddit?

Nope lol just got the same name I suppose

 

[marktuan]

Felbamate and Cenobamate, both carbamate derivatives, may have effects similar to mebrobamate or soma, although their specific abuse potential remains unclear due to their selective action on the GABA A receptor. Parempanel, an AMPA receptor antagonist, has been suggested to possess abuse potential compared to placebo, with claims of dissociative effects akin to ketamine; however, these assertions require further validation, especially considering that another AMPA antagonist, Topamax, is generally not associated with recreational use. sports games

Fenfluramine, an amphetamine-like compound, is reported to significantly increase serotonin and, to a lesser extent, dopamine, which might lead to stimulant-like effects, but more information is needed to assess its actual abuse potential. Ganaxalone, a neuroactive steroid that modulates GABAA receptors, is also controlled and warrants further investigation regarding its side effects and potential for misuse. Lastly, lacosamide is controlled as well, possibly targeting 5HT2 or 5HT1 receptors, which raises questions about its psychedelic activity.

In contrast, primidone, a prodrug of phenobarbital, appears to have no abuse potential according to personal experiences, but insights from others who have used it could provide a broader understanding. Overall, each of these medications has distinct characteristics and varying potentials for abuse, highlighting the importance of ongoing research and shared experiences among users to better understand their effects and risks.