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  • BDD Moderators: notsmokeymcpot42088

A way to stop precipitated withdrawal?

X

xburtonchic

Bluelighter
Joined
May 17, 2011
Messages
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The reason I'm asking is because sometime in the next few days (possibly tomorrow) I want to try a little experiment. I am going into detox very soon, but I want to keep myself well until then (obviously). The problem is that I am running out of money. I get paid every Saturday, but it's not much and so toward the end of the week I usually find myself dopesick more often than not. My solution to this is to take little "breaks" for a day or so, using Suboxone.

But what prompted this experiment (which I am getting to), is that the last time I got dopesick, the 2mg of Suboxone I took didn't even make a dent in it (they're the 2mg pills. I don't know why he gave me such a weak dose, I guess he's just an ass but oh well. You gotta work with what you have, right?)

As for my experiment: it's Saturday, so clearly I'm good to go right now. What I'd like to do is take a little experimental break while I have the comfort of knowing I have something there in case it gets too unbearable, and besides, it somewhat has to do with my little "experiment". Since the Suboxone didn't work last time, I want to play around with timing and dosage... you know, figure out exactly how much I need and when to take it in order for the Subs to actually take effect.

I will wait until I feel like shit and I will be utilizing the COWS worksheet. However, the chance of precipitated withdrawal is still there, and I am somewhat terrified of it. Normal withdrawals are horrible enough as it is... I'm very sensitive to them... to the point where I even found myself wondering today whether I actually have a phobia of them or something lol. I wonder if that's a real phobia... withdrawalaphobia...

Anyway, that's where my question comes in. I'm sure you know where I'm getting at, but I'll ask it anyway. If you are in precipitated withdrawal, will a dose of your DOC stop it in it's tracks? And if so, would a normal dose do, or would you have to take a slightly higher dose than usual? If it doesn't work, is there ANY way to stop precipitated withdrawal? Does anyone have a theory that might make sense even through logic? There has to be... medical science is so advanced and understanding of addiction and the way it works in the brain has come so far... it's incredibly hard for me to believe that there is absolutely no cure for something like precipitated withdrawal. :o

Scratch that, I have another question... what exactly is the pharmacology/physiology behind precipitated withdrawal? What I don't understand is why it even happens to begin with. I understand buprenorphine is only a partial agonist, but it still has a higher affinity to the opiate receptors. Since this is the case, why does it not occupy the receptors once it knocks the full agonist off? Since it has a higher affinity, it only seems logical that it would then bind to the opiate receptors... therefore preventing precipitated withdrawal. I hope that question made sense. Maybe somebody can answer? In laymen's terms please... I'm not a medical student or a doctor lol.

Hopefully someone has some insight into both of my inquiries... that would be awesome... of course, I'm mostly wondering about my first question - whether one's DOC would be enough to bring them out of precipitated withdrawal, and if not, whether there is any other way to do it. Thanks!
 
Here is a thread on that topic that should answer some of your questions. Here is another thread that is short, but has a few peoples experiences.

There seems to be conflicting answers. I noticed that somebody said that they took 8mg sublingual and got PWs after 20 minutes and kept doing dope to try to make it stop but it didn't help. I think that it might depend on ROA, because if you take it sublingually the drug is in your system for longer, and doesn't peak for a few hours, which is no wonder that it still blocks for a while, and even if the dope did take to the receptors more bupe would still be coming in to rip it off.

The people that IV'd their doses seemed to be able to stop the PW's by doing more of their DOC, and I think that this is because the suboxone is already being eliminated from their system after IVing it.
 
As they say, it all depends this accounts for the different responses due to different situations. Are you using a short lifed drug like oxycodone? or a long term such as methadone or opanas. But to answer your question basically, buprenorphine is an partial agonist on one opioid receptor and a antagonist at the mu receptor which is what is most effected by most powerful opiates. so yes the bup is binding to some receptors and allowing partial good feelings, as it overtakes the mu receptor it shuts it down. this becomes an instant shock to your body. this is why it is so important to be sure the full agonist is COMPLETELY off the mu receptor. when it is, the bup will latch on to both receptors and at even low doseages should equate to releif of what id say maybe a methadone. but as your body no longer relies on the mu receptor, you will again have those lovely feelings as the bup latches to the other receptor and gives releif equivalent to 30 mgs of methadone. hope this helps wish i would have been as interested before i induced my own precipitated withdrawal.
 
ThaKid85 said:
basically, buprenorphine is an partial agonist on one opioid receptor and a antagonist at the mu receptor which is what is most effected by most powerful opiates. so yes the bup is binding to some receptors and allowing partial good feelings, as it overtakes the mu receptor it shuts it down. this becomes an instant shock to your body. this is why it is so important to be sure the full agonist is COMPLETELY off the mu receptor.
Click to expand...
This is the best explanation I have heard yet as to why a partial-agonist would cause precipitated withdrawals.

ThaKid85 said:
help please is anyone there
Click to expand...

What do you need help with?
 
i have been on a daily dose of 30mgs methadone a day for two years, doc had me switch to suboxone and i took 8mgs sub after waiting only 12 hours after last methadone dose. the pwds were terrible of course, but my question is now that it has been 60 hours since methadone dose, and since i knocked off all the methadone from the receptors, should i take more and more sub till i feel better? not too much but would a higher dose help me sleep at least?
 
doesnt answer my question, since i induced severe withdrawal and it being 50 or so hours since then, will a dose of sub help, make it worse, or no effect
 
I'm so sorry ThaKid85, I had to go do something so I didn't see your posts til now. It is my best guess that you can take more Suboxone now and it should help, but everyone is different so I can't guarantee it.
 
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