I am a high purity street racetamic amphetamine user and I have a few questions that concern me
1. Why is the action of amphetamine divided into two stages? At the beginning of the action, euphoria prevails, which then gives way to stimulation in robot / zombie mode. Is this due to the fact that the half-life of levoamphetamine is longer, or for other reasons? Perhaps this is due to the conversion of dopamine to norepinephrine? I also assume that this is a consequence of the body's reaction to the introduction of a substance - the absorption phase corresponds to the euphoria phase, with the onset of the elimination phase, euphoria is replaced by stimulation. But this is just a guess. Is there a biphasic trend with d-amphetamine? Is it possible to stretch the euphoria phase for the entire duration of the action? Perhaps nmda antagonists will help with this?
2. Why is intranasal use so different from oral? At an equivalent dosage, intranasal ROA appears to be harsher and more unnatural, less controllable, more forced stimulation without goal-directed motivation. While the high of euphoria at the beginning is really amazing, it fades too quickly and is replaced by a zombie mod with an over-obsession with every action, and due to a short peak, the compulsive re-dosing becomes uncontrollable. That's why I hate the intranasal way and prefer the oral way, which seems cleaner and much more voluminous, rather than artificial and superficial. However, with intranasal, I seem to have far fewer peripheral side effects.
I believe this may be due to the fact that levoamphetamine, when passing through first-pass metabolism, cannot effectively cross the blood-encephalic barrier, and when administered intranasally, this occurs due to absorption into the systemic circulation and through nose-to-brain delivery. Due to the latter mechanism, levoamphetamine effectively penetrates the brain, acting locally in it and contributing to mental hyperactivity and anxiety due to excessive release of norepinephrine. The more the substance enters the brain directly, the more mental neurosis and fewer peripheral side effects. This is an assumption based on a combination of theory and subjective feelings.
1. Why is the action of amphetamine divided into two stages? At the beginning of the action, euphoria prevails, which then gives way to stimulation in robot / zombie mode. Is this due to the fact that the half-life of levoamphetamine is longer, or for other reasons? Perhaps this is due to the conversion of dopamine to norepinephrine? I also assume that this is a consequence of the body's reaction to the introduction of a substance - the absorption phase corresponds to the euphoria phase, with the onset of the elimination phase, euphoria is replaced by stimulation. But this is just a guess. Is there a biphasic trend with d-amphetamine? Is it possible to stretch the euphoria phase for the entire duration of the action? Perhaps nmda antagonists will help with this?
2. Why is intranasal use so different from oral? At an equivalent dosage, intranasal ROA appears to be harsher and more unnatural, less controllable, more forced stimulation without goal-directed motivation. While the high of euphoria at the beginning is really amazing, it fades too quickly and is replaced by a zombie mod with an over-obsession with every action, and due to a short peak, the compulsive re-dosing becomes uncontrollable. That's why I hate the intranasal way and prefer the oral way, which seems cleaner and much more voluminous, rather than artificial and superficial. However, with intranasal, I seem to have far fewer peripheral side effects.
I believe this may be due to the fact that levoamphetamine, when passing through first-pass metabolism, cannot effectively cross the blood-encephalic barrier, and when administered intranasally, this occurs due to absorption into the systemic circulation and through nose-to-brain delivery. Due to the latter mechanism, levoamphetamine effectively penetrates the brain, acting locally in it and contributing to mental hyperactivity and anxiety due to excessive release of norepinephrine. The more the substance enters the brain directly, the more mental neurosis and fewer peripheral side effects. This is an assumption based on a combination of theory and subjective feelings.
