Stimulants A few questions about d,l-amphetamine

[ninjapirateroberts]

Thank you sir lol

….and btw RATS having a mammalian CNS just like ours sand any drug will have the same effects as ina dog, a chimpanzee and a human.

…..and yes, other research exists as well

Soooo…..to Ninjapirateroberts…..PISS OFF ya bloody wank’a

Lol, “piss off”? Seriously?

You had no fucking idea what you were talking about and now you take advantage of the situation once negrorogesic came up with something. You have no knowledge of your own.

The abuse towards me is never warranted. Shows your maturity level. Waste of time talking with an amateur like you. What a loser!

 

[negrogesic]

He also self-contradicted himself by first saying "some" study was conducted on humans through "double-blind / placebo-controlled" (subjective experience on humans without pharmacological explanation) but later he said "not anecdotal garbage".

There is a double-blind on the subject. Heal et al. conducted a double-blind where male volunteers received a single dose of either d-amp alone or a combination of l-amp and d-amp (forgot if it was racemic or in the proportions of adderall). In any event, they found that co-administration of l-amp with d-amp resulted in something like a 15-20% increase in the maximum concentration of d-amp (and a similar increase in the area under the concentration curve, compared to d-amp alone.

I believe its mentioned in here, my institution seems to have lost access and I don't want to log into my other institution because the 2-factor authentication is on my laptop:

https://journals.sagepub.com/doi/abs/10.1177/0269881113482532

But lets cool it down in this thread, not a subject worth getting hot and bothered about.

 

[G_Chem]

Yo guys it’s cool to be debating on this, I myself have wondered on some of this stuff. Let’s keep things civil. Name calling and such ain’t gonna be tolerated.

-GC

 

[Dextro .45]

Lol, “piss off”? Seriously?

You had no fucking idea what you were talking about and now you take advantage of the situation once negrorogesic came up with something. You have no knowledge of your own.

The abuse towards me is never warranted. Shows your maturity level. Waste of time talking with an amateur like you. What a loser!

Bro…..ya, I know we’re both from Canada, but seriously man……take it eaz

For fun after I clean all my guns after a range session I spend endless hours reading medical journals, American, Canadian studies, whatever……many, many, many legitimate pharmaceutical studies, specifically dealing with controlled substances and pharmacology in general, the CNS in general, ADHD, neurological disorders, treatments that are approved, ones in trials with potential

My buddy over there just showed you another study on that matter……I personally have read about 3 medical journals published from well respected medical establishments

So like I said….I don’t have the time to dig up proof to show you. Do your own research

Seriously, let’s just end it with this back and forth…..they’re solid facts. Period.

All the best brother

 

[tryptakid]

We live in a time where people post all sorts of nonsense on message boards and forums, making claims that may sound plausible and also don't provide any factual information to back these claims up, whether they're correct or not. Places like this exist for people to come together, bring information with them, and share it, so that we can all have more informed awareness about drug use. I've heard way too many people make confidently incorrect claims regarding drugs that I absolutely knew to be false, perpetuating misinformation and mythology about drugs in ways that muddy people's understanding of this stuff. Confronting people on this can turn unnecessarily hostile (literally as evidenced by this thread), and can be avoided by double checking and linking something to verify what you're saying.

Is this topic going to dramatically effect someone's use from a harm reduction standpoint? Probably not, but that's not the point. The point is that we're all liable to misremember, make claims that we swear are true, only to realize later that we're mixing up a study we read, or repeating a mistruth they'd heard from a friend. Being a good member of communities like this is doing that little bit to back up what you're saying. This may be one of the only places someone visits when learning about drugs, and the fact that it exists for free is a gift.

Telling someone to 'do your own research' is shitty and dismissive, if you're making claims, take the extra time to show some of your own work. Who knows, you might learn something new in the process!

My $.02

 

[Twisted_Chemist]

Here is a quick, down and dirty breakdown between the two

Amphetamines are central nervous system stimulants that come in different isomeric forms, with the most common being racemic amphetamine, dextroamphetamine, and levoamphetamine.

Racemic Amphetamine (DL-Amphetamine)**
- **Composition**: Racemic amphetamine is a 1:1 mixture of two enantiomers: dextroamphetamine (D-amphetamine) and levoamphetamine (L-amphetamine).
- **Pharmacological Effects**: This mixture exhibits both the effects of dextroamphetamine and levoamphetamine, although the D-isomer is more potent in its CNS effects. The L-isomer has relatively more peripheral activity (e.g., effects on the cardiovascular system).
- **Uses**: Racemic amphetamine is used in medications like Adderall, which is commonly prescribed for Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy.

Dextroamphetamine (D-Amphetamine)**
- **Composition**: Dextroamphetamine is the dextrorotatory isomer of amphetamine. It is the more potent of the two isomers in terms of its effect on the central nervous system.
- **Pharmacological Effects**: Dextroamphetamine primarily increases the release of neurotransmitters like dopamine and norepinephrine in the brain, leading to heightened alertness, focus, and energy. It has a stronger effect on cognitive enhancement and less on peripheral effects compared to the racemic mixture.
- **Uses**: Dextroamphetamine is used in medications like Dexedrine and is prescribed for ADHD and narcolepsy.

Levoamphetamine (L-Amphetamine)**
- **Composition**: Levoamphetamine is the levorotatory isomer of amphetamine.
- **Pharmacological Effects**: Levoamphetamine has a weaker central nervous system stimulant effect compared to dextroamphetamine but has stronger peripheral effects (e.g., increasing blood pressure and heart rate).
- **Uses**: It is less commonly used alone but is part of the racemic amphetamine mixture found in some medications.

Summary of Differences
- **Potency**: Dextroamphetamine is more potent in its central nervous system effects compared to levoamphetamine.
- **Peripheral vs. CNS Effects**: Levoamphetamine has more pronounced peripheral effects (cardiovascular) than dextroamphetamine.
- **Usage**: Racemic amphetamine combines the effects of both isomers, making it useful in a broader range of therapeutic applications.

Sources for more information found in this post

- Stahl, S. M. (2013). *Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications*. Cambridge University Press.
- Fleckenstein, A. E., Volz, T. J., Riddle, E. L., Gibb, J. W., & Hanson, G. R. (2007). New insights into the mechanism of action of amphetamines. *Annual Review of Pharmacology and Toxicology, 47*(1), 681-698.
- Heal, D. J., Smith, S. L., Gosden, J., & Nutt, D. J. (2013). Amphetamine, past and present–a pharmacological and clinical perspective. *Journal of Psychopharmacology, 27*(6), 479-496.