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Tryptamines 5MeO-DMT potency calculations

S

scabbard

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Joined
Apr 2, 2024
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Looking for some advice to confirm if my calculations/formulas are correct:

5MeO-DMT freebase:
Molecular formula: C13H18N2O
Molecular weight: 218.3g/mol

5MeO-DMT HCl salt:
Molecular formula: C13H19ClN2O
Molecular weight: 254.8g/mol

5MeO-DMT fumarate salt
Molecular formula: C17H22N2O5
Molecular weight: 334.4g/mol

Potency of HCl salt compared to freebase = 218.3/254.8 = 85.7%
Potency of fumarate salt compared to freebase = 218.3/334.4 = 65.3%
Potency of fumarate salt compared to HCl salt = 65.3/85.7 = 76.2%

Thanks!
 
scabbard said:
Looking for some advice to confirm if my calculations/formulas are correct:

5MeO-DMT freebase:
Molecular formula: C13H18N2O
Molecular weight: 218.3g/mol

5MeO-DMT HCl salt:
Molecular formula: C13H19ClN2O
Molecular weight: 254.8g/mol

5MeO-DMT fumarate salt
Molecular formula: C17H22N2O5
Molecular weight: 334.4g/mol

Potency of HCl salt compared to freebase = 218.3/254.8 = 85.7%
Potency of fumarate salt compared to freebase = 218.3/334.4 = 65.3%
Potency of fumarate salt compared to HCl salt = 65.3/85.7 = 76.2%

Thanks!
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Well done sir. Safe travels.

calculating your own Molecular weights is sometimes very important. don't trust websites
 
although the freebase is smokable which has rapid absorption in the lungs producing a much stronger and shorter experience.
and the salts come on more slowly through the digestive system, as in AYA-like preparations. but this is 5me-O - a different beast from nn-
 
Speaking from experience, smoking the hcl and the fumarate are pretty much identical in effect and duration to the fb. They're just weaker.

A few years back I had some fumarate. Not recommended but would eyeball it. A single match head to get me there. 2 full match heads and I'd possibly speak to God. 3 match heads I would essentially white out.


scabbard said:
When it comes to God, I wanna make sure I've done my homework
Click to expand...
Again travel safe. If it's your very first time plz plz have a sitter. I've seen people do some pretty crazy shit on 5-meo-dmt
 
pupnik said:
although the freebase is smokable which has rapid absorption in the lungs producing a much stronger and shorter experience.
and the salts come on more slowly through the digestive system, as in AYA-like preparations. but this is 5me-O - a different beast from nn-
Click to expand...

Certainly. Different ROI's will have different curves in terms of the intensity the experience and the duration. I just wanted to get a baseline number comparing, gram per gram, how potent each molecule actually is.

Didgital said:
Speaking from experience, smoking the hcl and the fumarate are pretty much identical in effect and duration to the fb. They're just weaker.

A few years back I had some fumarate. Not recommended but would eyeball it. A single match head to get me there. 2 full match heads and I'd possibly speak to God. 3 match heads I would essentially white out.



Again travel safe. If it's your very first time plz plz have a sitter. I've seen people do some pretty crazy shit on 5-meo-dmt
Click to expand...

I didn't know you could smoke the fumarate. That's good to know. Because dosing small quantities of the FB molecule is difficult. My scale only goes to 1mg, and the difference between 5mg, 10mg and 15mg is astronomical for this molecule.

I will definitely be safe, thanks for the cautionary words. It's certainly not my first time, and I will have a sitter. I've done it on my own before but only in small doses from a vape pen. But I would not feel comfortable taking a standard dose and not having someone to watch over me while I'm having the experience. If I can't get in a good headspace, then I always struggle to have a therapeutic experience (that's what I'm using it for). But what's worse is when I am in a good headspace going in and then I feel inhibited because I'm not in a safe place where I can freely release and process and feel whatever needs to move through me. I've made that mistake before, and I won't let it happen in the future.
 
scabbard said:
I didn't know you could smoke the fumarate. That's good to know. Because dosing small quantities of the FB molecule is difficult.
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It's generally not recommended to smoke fumarates as they decompose into the freebase and maleic acid with heat? Thats at least what I've read somewhere...

the maleic acid dose would be miniscule, especially with such a potent compound, so I've taken the risk.

They're also more stable in potency amd physical consistency.
 
perpetualdawn said:
I'm curious about nasal sprays, how do people do this? I've only snorted 5-meo-dmt, I imagine that a spray would be more pleasant in the nose.

Seems like a lot of people boof it too.
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I dissolved mine in normal saline. The nasal spray bottle I used put out about 120mg per shot. The fumarate dissolves easily. So with a 60:1 dilution, you'd get roughly 2mg of medicine.

It comes on more slowly compared to vaping; it's a longer climb to the peak.

I did not like the experience of the spray in my nose, but it's probably more comfortable than snorting, though I've never tried that.
 
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