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5-Methyl-MDA Whats the deal?

oxalic32

oxalic32

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Jan 17, 2009
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5-Methyl-MDA is mentioned for the first time by Shylgin & Nichols [1] and does look like a pretty interesting compound. It substitutes for (+)MBDB, MMAI, and DOI in their rat models suggesting effects something like perhaps a combination of MDMA and LSD. It has less than one-tenth the potency of MDA as a dopamine uptake inhibitor, which would prevent the serototoxic effects associated with MDA due to extracellular dopamine. It is more than 5 times more potent than MDA in inhibiting uptake of serotonin suggesting a suitable human dosage of 15-25 mg. It would be interesting to hear reports of human consumption of this novel substance. An open question - Is the dopamine uptake inhibition of MDA and MDMA an essential component of their empathogenic properties? The experimental is enclosed here and it seems pretty straight-forward. 2-Methyl-MDA has about the same pharmacological profile as 5-Methyl-MDA, but 6-Methyl-MDA is much less potent, even less so than MDA.
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1) Has anyone dosed it?
2) If you could get it would you take it?
3) How safe is it considered to be?
 
It would probably be safer to take than MDA. If I had a chance to try it, yes I would. I've been looking a lot at the selective serotonin releasing agents that Nichols has made.
I think there's been several threads about it in ADD. Check those out, and also the MDAI thread about it.
 
Well i've taken MDA. it should be safer. MDA is an absolutely amazing tool for therapy.
 
Hmmmm, so I just looked at the original research paper, and 5-methyl-MDA and 2-methyl-MDA substituted for DOI at approximately the same dose that they substituted for MBDB. So it sounds like it increases the psychedelic effects. I wonder if it still retains the empathogenic effects.

edit: duh. says that in the first sentence of the quote. I should read more often.
 
my vendor, I only use one as they are so reliable and honest, has this in synth, so as soon as I get some I'll do a TR, Im quite excited.
 
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