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(5-MEO-MIPT/METHYLONE/MXE) - First time combo - 'sAll good

Crashing

Bluelighter
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Oct 15, 2012
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in coincidence.
Yesterday afternoon i received some pure 5-meo-mipt, alongside some 'mid-grade' mxe and a big solid yellow rock of methylone. The whole trip-event was unplanned and lasted roughly 16 hours.

My scale broke, so unfortunately i'm not really sure about dosing.

I decided to try the 5-meo-mipt smoked for the first time, because i figured it would be a safer way to accurately titrate up to a level i was comfortable with - So I just vaped the salt right off foil, smoking little piles smaller than match heads a few times until i felt that i was fully tripping, waiting about 5 mins between each hit. It tasted very similar to DMT, and the trip itself i can describe best as a 30 minute DMT rush followed by what i would call a 4-6 hour 'mushroom-roll'. It had strong attributes of DMT and mushrooms, with hints of LSD and MDMA. The trip was actually very powerful, i wasn't really expecting a +++ from this compound to be so mushroom-esque and was expecting more of an mdma type of feeling, but i was quite pleased nonetheless. Remember i have no idea how much i took but ii can imagine t was probably on the higher end of the dosing scale.

+3 hours - Begins the bumps of mxe. I started small and found that the two played very well together, although i wouldn't recommend the combo to just anybody. The level of disorientation was extremely high, and the trip became a more hedonistic and playful event than anything. I was extremely intoxicated after a few bumps of mxe and went out to the store to get some childish toys like glowsticks and straws, anticipating the long awaited marriage of pure methylone and our faces. I felt extremely uneasy at the cashout line, thoughts racing, typical tripping in public type happenings... peoples faces morphing, inanimate objects bouncing around, floors melting (think the Casino scene in Fear and Loathing) Clear, inorganic shapes that normally wouldn't be seen blobbing in and out of the perceptual field all over the place. Intense.

+6 - 10 hours - Begins with the large lines of Methylone. We just started 'Going Ham' on the methylone and mxe, only after we realized all played nicely together. I believe the aftereffects of the 5-meo-mipt were significant here but at this point it was hard to tell. The methylone had my body buzzing and feeling extremely 'rolly' and euphoric, while the MXE brought about a powerful insightful and introspective aspect to the trip. I can't really be totally accurate on dosing, but between 3 people we consumed about half a gram of MXE (remember it's 'midgrade' so the actual amount of mxe is unknown) and 1 gram of seemingly pure methylone. The effects were paramount. Extremely euphoric, very rolly but just as trippy. Not really much in terms of visuals other than spacial distortion and disorientation akin to large doses of alcohol without the sloppiness.

At the time, the two people i was with were amidst some relationship obstacles so-to-speak.. The trip i was on allowed me to willingly shift my conscious plane between 3 levels of existence. That was, Myself - Friend A, Myself - Friend B, and Myself - Friend a - Friend B. The psychological understanding was monumental. I felt as if all the communication problems between one and the other, one and myself, and all three of us were layed before me into imaginary shapes that i could understand only in a language that cannot be depicted in a textual context. I was able to view and understand all of their 'problems' or misunderstanding, and saw all the solutions and visually saw where the pieces could fit together and make a 'whole love'... if that makes any sense.

Anyway, the combo seems safe, and namely the methylone + mxe was both extremely enjoyable and also seemed to me to have extremely, EXTREMELY high therapeutic potential. I could see this being a catalyst in deep psychological reorganization. I have never, ever felt more connected to a 'source of information' in my life. I have had dozens of +++ and ++++ trips on everything from MDMA, LSD, K, DMT, Shrooms, and a ridiculous plethora of RC's and also a wide variety of combinations of many things and this was by far the most Clairvoyant experience i have seemed to ever have. I know the 5-meo-mipt played into this, but to what extent and how i am not sure, and im not sure how it would have been had i took them all together.

Anyway, just food for thought. Hope someone finds it interesting. Wish i could explain the intense moments more, but words just cannot do it. Methylone and other empathogenic drugs have always opened me up to being very sensitive to others emotional grounds, whereas MXE for me has always opened me up to the direct observation of an entire plane on reality that i am not normally aware of, one which is very hard to conceptualize and talk about after the fact. The combination of the two was one of the best trips i have ever had.
 
Interesting combo, be careful mixing 3 rc's without a scale, I know you are experienced though. Also I should warn you, I have heard mixing serotonergic stimulants with Mxe has been know to cause adverse effects like serotonin syndrome. The only know death from Mxe was in combination with a strong serotonergic similar to your methylone. Just be careful and enjoy yourself!
 
MXE has significant affinity for the serotonin transporter and doesn't appear to play well with other serotonergic compounds, 'foxy' and methylone both being examples of such. I wouldn't take this combination again.

ebola
 
Interesting. The combination was taken by two males and one female. Nobody had any hint of adverse/negative reaction or effects. I am wondering if when titrating there are any warning signs for the beginning stages of serotonin toxicity? I also wonder if the order of administration would have any effect on this. For some reason i feel like if i was on a strong dose of MXE and then started adding methylone, it would have been far less side-effecty, but i don't know if there is any sense in that.
 
Well, while there has been research confirming MXE's serotonergic action, there have only been scattered anecdotes suggesting that it combines poorly with serotonin releasers. I'm pretty cautious in that I'd want to avoid a combination that induces adverse effects only 1 percent of the time. As for how to more safely titrate, the only advice I can give is to use low doses of every compound involved.

ebola
 
I believe that i safely titrate, doing specs with waiting periods. But about that - I don't think there are any combinations (or non-combination) that doesn't cause adverse effects at least 1% of the time. As far as MXE goes, i personally can only speculate but i thought that it was probably only or mainly just a mu opioid agonist, domaine re-uptake inhibitor, NMDA antagonist, and maybe sigma agonist. I haven't read or (perhaps) observed any serotonergic activity within this compound?
 
As far as MXE goes, i personally can only speculate but i thought that it was probably only or mainly just a mu opioid agonist, domaine re-uptake inhibitor, NMDA antagonist, and maybe sigma agonist. I haven't read or (perhaps) observed any serotonergic activity within this compound?

In vitro binding affinity screenings have been conducted. Out of the mechanisms you list (and a couple of others), MXE acts solely as an NMDA antagonist and SERT inhibitor. This finding is pretty surprising, particularly given that SAR suggested possible mu agonism and subjective effects suggested affinity for DAT.

ebola
 
Ebola, I may have been the first to report that certain stims & mxe do not mix...

Briefly, I am more sensitive than most to both the positive & negative effects of almost all chemicals, & I generally use only sparsely so maintain a low tolerance as well. On seperate occassions I used various different stimulants with mxe, Butylone, Mephedrone & 4-fa.

On each occassion, even the mephedrone combo which was a cock-up, once the general stimulation eased I was left with a lingering, deeply anxious, tense, stimulated feeling, a headache, backache, chest pain & persistant nausea. I had had no such problems mixing meph & Ket. As such I concluded that mixing mxe post-stimulant use (such as is often done with Ket) might prove problematic with hypertension & anxiety at the very least & I posted as such here 2 or 3 years ago.

I was certainly amongst the first few hundred or thousand to actually buy Methoxetamine, back when a well known UK RC supplier introduced it, though I soon decided Dissociatives aren't really for me.

Back then, I found 5mg of aMT & 10mg of Methoxetamine, was a sweet hit for me, illustrating my low tolerance & usually cautious use.
 
Have you ever combined MXE and a non-serotonergic stimulant?

ebola

Yup, I used to use it with mpa, they were both appearing around the same time. As usual, pretty low dosing, 10mg of mxe followed by regular 10mg lines of mpa. Don't like mpa anymore.

Also, a mate of mine known personally to me, someone with even less tolerance & even greater sensitivity to stimulants than me, but with a love of Dissociatives, loves to combine Methoxetamine with 4-fa, in much lower doses than I would use 4-fa. For instance, the sweet spot for him is 25mg Mxe & 25mg of 4-fa. This dude suffers none of the symptoms I describe, but I always put that down to the lower dose of 4-fa. I would have at least 100mg of 4-fa & often 180mg (but no more) back when I did that sort of thing. I only combined a small 10mg line of mxe once wth an average dose of 4-fa but suffered the same unpleasant after-effects described above.
 
I could imagine that mixing MXE and something like 4-FA would be pretty bad feeling and possibly dangerous. Methylone for me doesn't really feel like a stimulant as much as what i would call an empathogen. It's weird, i would call 4-FA, adderall, coke, a-pvp, meth etc... stimluants, in some cases euphoric stimulants. Methylone is in a different category for me, between stimulants and psychedelics i guess. It's very subjective, but i don't think i would ever mix 4-fa and MXE for whatever reason.

I have to add also that i am usually very sensitive to stims, basically only doing half or less of my using buddies or whatever you wanna call em.
 
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