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5-htp preload?

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natz420

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Sep 24, 2012
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so on friday i did about 200 mgs of bzp and 100 mgs of tfmpp...and was hi off my ass, seriously, but then next day i tried it again and felt almost no effects. im assuming this is due to the fact that i "used up all my seratonin" the night before. prior to this bzp/tfmpp mix on friday ive been doing alot of coke and mdma for about 3 weeks 2-3 times a week. and prior to those 2-3 weeks ive had very minimal drug use. so due to the fact i felt almost nothing on my second bzp/tfmpp trip im worried i have no seratonin left....and im due for a crazy rave this saturday and i need to ensure i get high again! should i preload with 5htp from now till this sat? should i take bzp/tfmpp at the rave or just mdma? i was so please with the bzp/tfmpp high that i would LOVE to do it on sat but dont wanna risk not getting high but i know i cant mix bzp and mdma cuz it will cause seratonin syndrome, so its either i do the bzp and risk not feeling much and no other drugs, or do mdma????...i dunno what to do!
 
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I know you don't want to hear this, but you need to take a long break, at LEAST 3 months! Personally I would go for a 6 month break, that's how long I waited after I overdid it and I still wish I waited longer.

If you keep trying to get high you are only going to cause more damage to your neurotransmitters! That's not a good thing!

I'm not 100% on this but I believe if you pre-load with 5-htp it can increase the risk or serotonin syndrome which is something you definitely don't want. (Please someone correct me if I am wrong!)

And if you are still inclined do go to this rave and get high...why not just try drinking or a different non-serotonin releasing drug?

Please do yourself a favor and take it easy, is getting high for a rave really worth greatly increasing your chances of LONG term brain damage?
 
ahhh not getting high is not an option! lol i did mdma a few times a week prior to the first bzp use and i still got high.....so im thinking the second bzp use failure was due to some kind of immunity??? cuz even if i do m 2 days in a row i still get hgigh the second day but why didnt i get hi the second time on bzp? im so confused im running in circles
 
what mr.md said, you really need a break. whether or not you get high on sat should be the least of your concerns, that amount of dosing deffinitely caused some damage. i have a few friends that are dependent on xanax and antidepressants because of mdma abuse. please be careful. since you just started doing this, theres a good chance of nothing permanent, but if you keep up that use pattern, youll have some serious emotional problems in a few months

take a break, exercise, eat healthy, and if you really wanna do something on saturday id recommend a 5-hour energy and one or 2 drinks

edit: preloading 5-htp with a serotonin releaser like mdma can cause serotonin syndrome
 
Well keep in mind you just completely drained your serotonin, so any drugs that release large amounts of serotonin to get you high their effects will be greatly reduced.

I still stand by my previous statement that you should take a long break from drugs in general after the amount of MDxx you have consumed in such a short period of time. Not to mention the bzp/tfmpp...

I'm certain everyone here will tell you the same thing seeing how this is a harm reduction forum...

But to try and answer some of your questions..

"Anecdotal evidence from online sources claim tolerance to the central action of BZP will develop quickly." - wikipedia

So your tolerance could just have shot up depending on your dose of BZP.

One again I know you don't want to here this but you NEED to take a LONG break...
 
Immunity? No, its tolerance, its PERMANENT down regulation of serotonin receptors. The "not getting high is not an option" attitude is not a good way to go about raving and using serotogenic drugs. Youre just asking for trouble-- and not just way down the line-- immediately, and also way down the line.

Youve already done a ton of damage. The MDMA abuse alone has been significant. Its probably hard to conceptualize because your head has probably been in the clouds for weeks. I get it. But I promise you that you cant keep your head in the clouds forever and you will suffer adverse effects.


I recommend a LONG (6+ month) break from all serotogenic drugs. I promise that this transcends any immediate need to "get high" at a rave.
 
i get that i need a break, im very much aware and will get on it asap. but this is a very big event and will be my last event and use of drugs for awhile. i only have acess to mdma and bzp. im leaning to wards just doing mdma bcuz i always get high off of it even if i do it 3 days in a row...i dunno what happenedwith the bzp why i didnt get high the second day, seems like that drugs needs a VERY long break inbetween use...so im thinking of just doing mdma bcuz i know i will feel something. although i really wanted to do the bzp i cant risk not feeling anything. and i know if i try it and dont feel much then do mdma i will get seratonin syndrom so i guess i will just do mdma but this will be my last roll for a very long time....back to the gym for me!
 
but ive heard preloading with 5htp greatly increases the high? ive read from many reports and forums that it does, but on the other hand i read alot that it mutes the high?....so theres no definate answer
 
natz420 said:
but ive heard preloading with 5htp greatly increases the high?
Click to expand...

In theory it can, but at the same time you risk giving yourself serotonin syndrome...

I've pre-loaded with it once before, the night before I rolled I took around 100mg (if my memory is correct, it was a while ago) and I noticed no difference from the previous roll, many users even report a less intense roll.

Here's a thread about it:

http://www.bluelight.ru/vb/threads/365334-5-HTP-before-Ecstasy
 
Wow, it's been a long time since I've heard about someone knowingly dosing piperazines :\

I would stay away from them. They seem to be much more toxic and damaging to users than MDMA.


Also, using 5-HTP in your state is asking for trouble... if you can't go without taking a break from drugs, taking a pill isn't just going to fix the problems that arise from it. The only thing that will really help you now is time away from drugs... I would recommend that you do just that.
 
i agreee piperazines seem to be very toxic, the after effects ive experienced from these things have been way more noticeable and seems to be more toxic than m, even after just one use, it lingers for days and days.....did m a few times a week for 3 weeks and felt reletively fine. did bzp 2 nites in a row and feel permafried.
 
There's your answer man.

if you're going to continue using piperazines, which I don't really have a problem with if you like them, but you really need to be doing it safely.

You're only supposed to do MDMA once every month, at the maximum. You probably need much longer than that to recover from piperazines. I've noticed the after effects to last a week or longer from one shitty pill, that's a lot less than what you took too


So no man, don't go taking any more drugs this Saturday. Maybe a psychedelic or something that doesn't release serotonin/dopamine, but it sounds like you need a nice long break to me :\

Good luck.
 
I just came across this thread and reading natz420's post, i just could not resist adding to the conversation.

I have been in your spot many times, and as a frequent clubber (basically every friday and saturday night) i have always been keen on finding ways to replenish serotonin and getting rid of the hangovers even quicker. So yea i also came across 5-HTP. And for me it does help a great deal, and this is how i use it (mind you, i'm always in a state of low or depleted serotonin since i drop at least once every two weeks but usually once a week):

After you roll wait two nights of sleep, so you are past that mellowy after-MDMA-use feeling. For me, this is usually monday morning. When i wake up i take one capsule of 5-HTP(50mg). Then roughly every 7 hours i take another one. Why 7 hours? I heard from a mate of mine (who actually studies medicine, so i assume the information is at least more reliable than a random source) that it takes that long for your body to process one capsule. I keep this up until thursday night. Friday i do not take anything at all because i want to give my body a break (at this point i feel like i have reduced the hangover for at least 50 percent and i feel pretty normal again anyway). Then when i drop saturday i feel almost like its as hard as i took it the very first time, getting effects again like eye twitching (before taking 5HTP i had to take a three week break to get that particular effect again).

Some other experiences i have had with 5-HTP:
- using 5-HTP when you drop for me makes it harder to get high
- taking 5-HTP one day after use causes mild headaches and confused feelings as well as getting extremely vivid and looooong dreams

Info about me:
- when i drop i try to keep the dose always as low as possible, but generally a night i consume 100-160mg mdma.
- when you try to buy 5-HTP you can choose from several variations it seems, those with added vitamin B and stuff, as well as the 100mg versions. I always get the most expensive one with the added vitamins and everything but no more than 50mg 5-HTP. I pay 26 EUR for 60 capsules.
- Every once in a while i also take really expensive (and big) vitamins pills. I want to take them more regularly but i dont always remember to. Maybe that is something to think about, if you want to do drugs, then at least spend a little more on staying healthy. I believe if one is able to spend 100s on pills, you should also take a little extra care for you body.
- i dont do any other drugs and maybe drin ka few beers when dropping

Sorry for the long post, hope it helps a bit. Cheers!
 
People seem to chide me for saying so, but 5-htp has been theorized to be somewhat cardiotoxic. This is due to conversion from 5-htp > 5ht via l-aromatic amino acid decarboxylase all throughout the bloodstream, before ever reaching the brain. ie lots of serotonin floating around your body where it isn't necessarily supposed to be.

I could provide sources but my battery is near dying and I don't feel like getting the charger. A simple google search will yield you much information.
 
^ 5-HTP was never meant to be taken by humans.. Naturally, you eat foods with L-Tryptophan and that's converted into 5-HT inside of the brain, meaning it can reach to the places it was meant to go.


but when you just take 5-HTP directly, it can't cross the BBB so like 90%+ is completely wasted. The rest of it that doesn't make it into the brain is filtered out by the kidneys... and could potentially cause damage to other organs as well.

That's why I NEVER take supplements. You need to get your nutrients naturally, supplements can give you large amounts of a neurochemical you don't need... that can cause some serious problems. We don't even know how the brain works, and you guys are trying to modify it with neurochemicals? That's playing with fire, IMO.


Like you said, it's not good to have extra serotonin floating around where it's not supposed to be
 
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