This is what I think about the ppl who have taken 5-HTP, and it not having an effect at all. You who fit in this category probably have a higher SERT level; which means you don't need it because you have a higher than average seratonin level, and your body already produces more than enough. That is my theory. To the indivuduals that it does work for; the opposite is probably true for those who fit in the low SERT kevel category. Meaning your body may under produce SERT which when you take 5-HTP it supplements for the loss that an average person would have. That is my theory on that. Now for the ppl who have been taking it since there MDMA usage; it is definitely a good idea to take before and after; not only for the replenishing of SERT, but also for it's potential antioxidant properties as well. I take 100mg before bed along with Mekatonin as well, and It puts me out very nicely. I have some pretyy awesome dreams by the way. It is satd when an individual takes LSD, 2C-B or any thing along those lines-also MDA-that the pineal gland releases melaonin while tripping. Just thought I would throw that out there.