5-htp and mephedrone

[girlygrrl]

Well this was unexpected.

I took a week off mephedrone to give myself time to detox from it.

Recently, I started taking 5-htp to help with MDMA comedown.

So after doing 5-htp for a couple days and not doing meph for a week, I drank a cup of 30mg meph dissolved in water for a "pick-me-up" and I swear it was stronger than the very first time I tried it. I had intense euphoria almost as if I was rolling and my eyes dilated.

I had no idea that 5-htp and some of the other post-MDMA loading I was doing would completely reset the tolerance on mephedrone, and in fact make it seem stronger than the first time I tried it.

Maybe my brain just doesn't produce enough serotonin. 5-htp does more to help depression than any other supplement I've tried (like St. John Wort which seems to do nothing for me at all) and I was completely blown away that it seemed to reset my tolerance for meph (I've taken a week+ off from it before and it didn't seem to change my tolerance level)

 

[eLW]

Why would you take mephedrone if you have acess to MDMA? How can it RESET tolerance? do you have some swtich ON/OFF in your head?? ahhhhhhhhhhhhhhhhhhhhhh,

 

[girlygrrl]

Why would you take mephedrone if you have acess to MDMA?

Because it is an awesome stimulant. It doesn't have a crash or hangover IME. I can actually be super productive when I'm on it. I feel just as safe driving on it as I would on caffeine. It is a hell of a lot better than drinking Monsters or Red Bulls IME. But generally I try to keep the doses low like 60mg or less and save "rolling" for the MDMA experience.

How can it RESET tolerance?

I don't know. But 5-htp is the only thing that I can attribute to a sudden decrease in tolerance. Either that or somehow my body wasn't finished metabolizing the mdma a couple days after rolling and the meph "woke up" whatever mdma was still in my system? 30mg of meph is barely threshold at best usually but when I did it it seemed like I had done like 150mg.

I wonder if anyone else has noticed if 5-htp affects their meph tolerance.

 

[Munroe]

Although there's not been any proper research done, it's assumed that mephedrone acts at least partially on serotonin.
The 5-HTP you took will have increased levels of serotonin giving the mephedrone "more to go at" increasing the high.
This is the same principle as pre-loading before MDMA rolls.

 

[girlygrrl]

But pre-loading mdma didn't seem to do much of anything for me, so why does pre-loading mephedrone "reset" its tolerance?

It baffles me although I'm sure there's a scientific explaination hidden there somewhere.

 

[Munroe]

A week off will have let your tolerance drop, and the amount of 5-htp you consumed leading up to it will have had an effect.

How many mg per day of 5-htp were you having this time in comparison to last time?

Stomach contents could have effected the absorption rate causing you to perceive the high to be stronger as it came on quicker.

 

[girlygrrl]

100mg/day 5-htp for 3 days before this time, no 5-htp at all last time.

I was much higher and it was stronger, plus my pupils dilated. That generally only happens on much larger doses like 150mg. I didn't feel safe to drive.

So yeah it wasn't just some minor tolerance decrease it was like I was dosing 100mg and it was my first time ever doing meph. But I only did 30mgs. So it was a bit shocking although pretty enjoyable.