I drink red bull while rolling all the time, but to be honest, ime no matter what it depends on the pill and everything else (how tired you are that day, etc etc). at times, the red bull really woke me up and kept me on my feet, but at other times, it did nothing and i continued to be floored. I imagine that with the 5 hour energy drink it would be pretty much the same thing. I never feel uncomfortable if I drink red bull while rolling, but that's just me. So it depends on the person. if I were you I would test it out (drink half of the 5 hour shot first because that gives you moderate energy rather than the extreme energy you get from the whole thing) and find out if you like it