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4AceT (4 Acetoxy Tryptamine)

Well, gladiolus, I have observed over the years that every time someone asserts something that goes against the "common knowledge", most people immediately dismiss it, whether it's as placebo or misidentified substance or something else. I remember when the 4-HO-Ts/4-AcO-Ts besides psilocin first became available, most people were saying that their effects were the same aside from duration and perhaps smoothness. Some people even said that all of them were pretty much the same as mushrooms (!). But not a lot of people say those things anymore.

I think the idea that all esters of 4-sub-Ts are simple prodrugs for the 4-HO-T is entirely too simple of an explanation that has been reached without full proof or understanding, based off the assertion than 4-PO-DMT is a simple prodrug of 4-HO-DMT (which we don't even know for sure). Why would someone extend that to ALL esters of ALL 4-sub-Ts? It doesn't make sense to me, and since my and many others' experiences have shown otherwise, to me it
s just plain not true until someone provides conclusive evidence, which I strongly suspect will never happen.

It's the same sort of thing going on here with your 4-HO-tryptamine and 4-AcO-tryptamine thing. The common idea is that they're not active, so many people are dismissing it out of hand as false. The difference here between your case and my example is that I don't know of anyone but you who has tried either one, so there is really only your word to go by. However, that holds weight for me, at least enough to consider the possibility and think about why (as much as I am able). :)
 
Can we merge this thread with the original?

4AceT (4 Acetoxy Tryptamine) Assay

Aloysius, thanks for the links. I'm glad we've moved past the use of cats and dogs for experiments like these.

There is additional data indicating that 4-HO-tryptamine has activity at the 5-HT1A/2A receptors, albeit with lower affinity than psilocin. The big unknown is whether or not it would make it to receptors in the CNS...avoiding immediate metabolism by MAO enzymes and crossing the blood-brain barrier and are two important steps. Considering the inactivity of 4-HO-NMT, it seems unlikely that 4-HO-tryptamine would have psychedelic activity, but as far as I know no tests have been done with a sample of confirmed identity.

Affinities for 5-HT2A (vs. 3H-ketanserin)
4-HO-tryptamine 724 nM (rat cortex; Engel et al., 1986)
4-HO-DMT 107 nM (cloned human 5-HT2A; PDSP)
4-PO-DMT >10,000 nM (cloned human 5-HT2A; PDSP)

An interesting piece of information that I just stumbled across is that psilocybin is completely inactive at the 5-HT2A receptor. I remember it being debated whether or not psilocybin could cross the blood-brain barrier with the bulky phosphoroloxy group, but it seems it would be inactive until metabolized into psilocin anyway. Same probably goes for baeocystin and norbaeocystin.

Gladiolus, have you had any more trials with the material?
 
there is well documented scientific literature that states that 4-HTP(4-hydroxytryptophan)is fully active orally as a 5ht2a agonist and hallucinogen
 
I would be surprised if 4-hydroxytryptophan had any effect. Are you sure you aren't referencing 4-hydroxytryptamine?

4-HTP is generally believed to be a precursor for psilocin in mushrooms but I've never heard anything of it being active on its own.
 
Again, i refer people to the reference earlier in the post.
There is no reason to suppose that the 4-hydroxyl group will not protect against some oxidase. There is no 4-hydroxy on record that is not active...?? I find it hard to believe that 4-HO NMT is not active but 4-AceT is. If this is true, then there is something truely remarkable going on .
 
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