4-methylaminorex ('ice')

[yasmapal]

Dude, I was seeing visuals that were DISTICTLY 5-meo-dipt visual and hearing those distinct audio distortions that come along with it SEVEN hours after hitting it up. I got more than a few mg.

 

[fairnymph]

Having tried the stuff (finally!) I've returned to answer my own questions:
* how much you did?
60 mg
* how long it lasted?
A good 14 hours.
Also, when does it peak/plateau, how long is the come up?
Come up very fast, within an hour. Extended plateau and very gradual comedown.
* how did you take the 4-MAR?
Orally 30 mg, snorted 30 mg.
Orally gave more euphoria and body high, snorting gave more of a headrush/buzz/speedy feel.
How does it compare to meth euphoria? More/less? How is it different from and similar to meth and MDMA euphoria?
I would say, slightly more euphoria than with meth. Not as much as with MDMA.
What about a body high/buzz? Again, how does 4-MAR compare to MDMA/meth?
Body high on 4-MAR is really nice, more similar to MDMA than meth.
In terms of rush, which provides a stronger rush -- meth or 4-MAR?
Meth, definitely. Meth is the 'rushiest' stimulant IMO.
As a stimulant (i.e. it makes you alert/keeps you awake), is 4-MAR more potent than meth, and in fact more potent than any other stimulant?
It keeps you awake for a really long time, and you definitely feel clearheaded, but I feel that meth has a slightly more 'stimulated' feel to it.
For those of you who have tried it, have you found that 4-MAR boosts your intellect/mental speed more than meth/more than anything else?
I would say that it is about equivalent to meth's effects, with the exception of writing abilities, which are significantly more improved on 4-MAR.
Overall, I don't find this drug to be that different from meth, and I'm not sure if I could say I prefer one. I do really like the rushy aspect of meth, but I love the gentle comedown on 4-MAR...
You can check out my trip report for further details.

 

[shneed]

fairnymph have you tried smoking it? All I have been doing is smoking it, if so how dos it compare to eating/snorting?

 

[fairnymph]

No, I haven't tried smoking it. I don't like smoking things.
It definitely works when you smoke it (at least according to my friends who seemed pretty fucked up), but has a nasty taste (which doesn't surprise me seeing as snorting it produced a nasty drip).

 

[quale]

Crazy. 4-Mar is so weird. How does it react to things like reboxitine and wellbutrin?

 

[shneed]

Does anybody have any information on the neurotixicty of 4-MAR or just toxicity in general. I read about one death in the Erowid journal section, I was just wonderin though if anyone has any sources or personal experience of damage done due to 4-MAR?

 

[fairnymph]

Administration of acute and multiple doses of 4-methylaminorex caused rapid (3-h) and long-term (7-day) declines in striatal tryptophan hydroxylase activity with few changes in other serotonergic parameters. The acute response by tryptophan hydroxylase to this drug was reversed by incubating the tissues in a reducing environment suggesting that 4-methylaminorex alters this enzyme through oxidative mechanisms. The 4-methylaminorex-induced long-term reduction in tryptophan hydroxylase activity might be due to neurotoxic action on serotonergic systems. In contrast, although a decline in striatal tyrosine hydroxylase occurred 3 h following a single dose of 4-methylaminorex, no changes in this enzyme were observed at 7 days after acute or multiple dosing with this drug. This result suggests that 4-methylaminorex is not neurotoxic to the dopaminergic neurons.
Hanson GR, Bunker CF, Johnson M, Bush L, Gibb JW. Response of monoaminergic and neuropeptide systems to 4-methylaminorex: a new stimulant of abuse. Eur J Pharmacol. 1992 Aug 6;218(2-3):287-93.

These data suggest that 4-MAX is a potent dopamine releaser, which decreases tryptophan hydroxylase activity in a manner similar to other amphetamine-related drugs. However, in contrast to other amphetamine analogs, 4-MAX has potent convulsant actions.
Bunker CF, Johnson M, Gibb JW, Bush LG, Hanson GR. Neurochemical effects of an acute treatment with 4-methylaminorex: a new stimulant of abuse. Eur J Pharmacol. 1990 May 3;180(1):103-11
Seems like 4-MAR is probably about as neurotoxic as meth, but really there hasn't been much research done on it...
The most interesting/dangerous thing about 4-MAR is that it is more likely to cause seizures/convulsions than other stimulants.

 

[sparklr]

How does it react to things like reboxitine and wellbutrin?
At the time, I was on a ridiculously high amount of wellbutrin (400 mgs/day). This doctor was nothing but retarded. I don't even know if I really need it, seeing as I shortly quit going to him and opted for a doctor that I could scam. I'm on 150 mgs/day now. And the difference didn't jolt me at all. But I digress.
Maybe the fact that I was on such a high amount of a dopominergic manipulator accounted for the 'impersonal, non-euphoric' effects that I've felt.
I don't know...I mean, there are conflicting opinions on the effects in this thread alone to really draw any conclusions. You know, maybe my dopominergic system isn't as sensitive due to my past cocaine abuse, maybe it was the wellbutrin, maybe a combo of both.
I mean, the only thing I can say is that I was on wellbutrin at the time and felt no euphoria at all.

 

[quale]

Hmm...interesting. Butsupposedly cocaine and meth are relatively unaltered by wellbutrin (according to fairynymph) but rebexetine completly blocks the effects (at least in one subject). I would be really interested to see what happens here.
Also I am still completly beguiled about how wellbutrin should have no effect while strictly more selective agents deystroy the high.

 

[fairnymph]

^^^
Do you know how to READ, fawker? My name only has ONE letter 'y'. The word 'fairy' is NOT part of my name. Get it right.
As for wellbutrin...apparently some people find coke to be BETTER on wellbutrin. Meth is mostly the same, from what I have heard...
I will be trying wellbutrin in about a week, perhaps I will see how 4-MAR interacts. I'm not willing to waste my ice by combining it with reboxetine, although I would predict that the high would still be somewhat intact. IMO, 4-MAR is very dopaminergic and fairly serotonergic, but notably lacking in norepinephrine release/modulation. You don't get any of the 'rushy/tingly' feelings which I would bet my life are due completely to norepinephrine (as I get these feelings on meth and MDMA, and also, the first two nights that I started taking the reboxetine).