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4-HO-MET Serotonergic Activity?

!!4iV4HF9R34g

!!4iV4HF9R34g

Bluelighter
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I am interested in a combination dose of 5-MeO-DALT and 4-HO-MET. However, it has recently come to my attention that 5-MeO-DALT may be quite serotonergic, and I am not interested in causing cardiac problems in the subject.
The subject is healthy now, though she has had heart problems in the past due to malnutrition.
 
But not all psychedelics will compound their effects to the point of inducing Serotonin Syndrome or cardiovascular distress or other physical problems related to levels that are too high. There are many compounds which you can effectively mix and be safe, and there are also chemicals that are unsafe to mix due to their respective levels of activity.

Your answer did not help at all.
 
I am sorry, I was trying to be helpful, there's no need to be snippy. What do you mean when you say that you have heard that 5-MeO-DALT is serotonergic? It is certainly a serotonin receptor agonist, as are all psychedelics, and so can cause long-term damage to the heart through 5-HT2b agonism if used to excess. However, I think you're asking about the acute danger of the combination, which is a different matter.

I don't think this is advanced, I'm going to move it to PD.
 
Yes, I'm sorry as well. I've done some research into this on various other forums, but none seem to have the technical knowledge that BL offers. However, I have been told that 5-MeO-DALT has produced adverse heart complications in at least one individual when combined with MDAI. I know that MDAI acts strongly on serotonin reception, and I figure that the massive levels of serotonin had much to do with the negative reaction. I also know that 5-MeO-DALT itself is a relatively potent agonist, considering the levels of euphoria and other correlatory effects. So my question in the thread's title was aimed at discovering whether or not it is known that the compound 4-HO-MET has a propensity to induce any adverse reactions due to excessive serotonin levels, or else to find any other related information. My goal is to make sure that this combination will be safe in a subject with a history of heart troubles.. I don't want her to be hurt..
 
MDAI works in a very different way to psychedelics. MDAI is a serotonin releasing agent, so it causes an increase in the amount of serotonin in synapses, but does not actually bind to the receptor as 4-OH-MET does. I won't speculate on the cause of the heart complications in the poster above, but I will say that I don't think that combining psychedelics at sensible doses is very likely to cause cardiac complications in healthy people. Worst you're likely to get is a racing heart from anxiety/exhilaration or whatever.
 
Yes 5-MeO-DALT is serotonergic but so is 4-HO-MET and virtually all other psychedelics (not counting other drugs with partial psychedelic aspects), it is not a simple explanation for 5-MeO-DALTs side-effects. The long term damage Vader is talking about is disputable and not realistic because it pertains mostly to long-term exposure to compounds that have significant 5-HT2B activity I guess like mephedrone and flephedrone etc.
The problem with 5-MeO-DALT may be something like beta adrenergic activity, I am not sure. Also not sure if it is remedied by a beta blocker or if that is even smart... but you can expect more panic or anxiety attacks from it when combined with another psychedelic. The combination with 4-HO-MET does not seem additionally dangerous though psychosomatic effects like confusion, fear and distress can make your heartrate go up which is not something you'd want on top of 5-MeO-DALT activity.

What kind of heart problems are we talking about here? Due to malnutrition, that sounds like irreversible problems and not true damage. Are you prone to anxiety? Chest pains?
Also, have you tried either compound by itself? It is a little foolish to consider such a combination without knowing the separate compounds in and out. Especially if you worry about aspects of your setting like your health!

We're all trying to help, but we don't have the total and clear truth on anything you ask ready on a silver platter, Vader doesn't and I don't either. If an answer does not help you, just be more patient. And (senior) modship does not mean we always need to be able to help as much as you want. Especially if it's not the domain of expertise. Vader is not particularly an agent of PD and neither of us are with ADD. While this is not necessarily an advanced (ADD) question, extensive knowledge on 5-MeO-DALT pharmacology - if it is even known!! - is indeed proximate to the advanced area.
 
While this is not necessarily an advanced (ADD) question, extensive knowledge on 5-MeO-DALT pharmacology - if it is even known!! - is indeed proximate to the advanced area.
Click to expand...
Yes, but explaining what "serotonergic" means isn't, you can move it back if/when the discussion is at an appropriate level :)
 
Well, thanks to both of you. I have tested both compounds separately, but I am an experienced psychonaut and do not have heart problems. The subject is a friend of mine who is new to psychedelics, and she has a history of anorexia which has led to her heart (and other organs) being underdeveloped.

I feel relatively confident that this would not cause an adverse reaction. I was simply interested to find out whether or not 4-HO-MET has any sort of history of heart complications. Thank you both for your help.
 
As I'm sure you know, 4-HO-MET is structurally very similar to psilocin, a substance that has a very extensive history of use and no association with heart problems. I have to ask, though, why you are giving a first-time tripper a combination such as this? I can appreciate that you may think that the compounds would complement each other well, but if it were me I'd at least try the combo first before dosing a debutante with it. I know you didn't ask, but I'm still just trying to help ;)

There's a big and dandy first-time tripper thread that might be of interest to you.
 
Well, I'm definitely going to try it myself beforehand haha! I just was doing some advance research for her.
I actually think that this combo would be a great first time experience though. Positive, even euphoric, and visually appealing, and even slightly empathogenic. (:
 
I'm no expert here, but a comparison of 5-MeO-DALT & MDAI to 5-MeO-DALT & 4-HO-MET is apples--->oranges. Miles apart. I'd say the problem in that combination lay in the MDAI.
5-MeO-DALT & 4-HO-MET should be just fine.
IME 5-MeO-DALT and 4-HO-MPT (yes, a different substance, but much closer to 4-HO-MET than MDAI) in combination was quite lovely with absolutely no hints of an adverse reaction. I'd just steer clear of MDAI in this individual.
Enjoy.
 
well, just my opinion... if she is a beginner, why not just go for the 4ho met? it still is very lovely chemical, positive, mild visuals at low(ish) doses.. why complciate things with combos? keeping things simple is the way to go when you start.
 
The long term damage Vader is talking about is disputable and not realistic because it pertains mostly to long-term exposure to compounds that have significant 5-HT2B activity I guess like mephedrone and flephedrone etc.
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Actually, lots of commonly used psychedelics have very significant 5-HT2b activity. Link. I agree that cardiovascular damage is only likely with chronic exposure.
 
Good. (: On a side-note: would 2C-I bring about any of the aforementioned complications?
I'm beginning to suspect that a dose of 2C-I might be better suited for my purpose.
 
2C-I is pretty stimulating, and IIRC the 2Cs have adrenergic effects, so might not be the best choice if heart trouble is a real worry... why don't you just dose her with the metocin, I'm sure that's plenty psychedelic enough for a n00b.
 
But it's not about the visual or trip aspects, it's more about strengthening the interpersonal bond and also about opening her eyes to her real Sight (you know?).
 
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