Stimulants 4-fluoroamphetamine

[sonic]

I haven't tried it, but I've heard mostly good things about it from a friend who basically pioneered this drug. It's supposed to be somewhat like a cross between oral METH and MDMA. There isn't that much out there on this drug. The few reports are all that exist.

 

[Limpet_Chicken]

Lol Nuke, the sarcasm is so cutting, its making my monitor bleed

A: F2 makes most things burn on contact.

B: surely you haven't forgotten about the toxicity of fluoroacetic acid/fluoroacetate salts, they get metabolised to fluorocitric acid, which can't be metabolised in the krebs cycle, nasty stuff, no antidote, and interestingly, its one of the very few and far between organofluorine compounds occuring in nature, produced by an S.african plant 'gifblaar' I think is the native name, or 'gifbol' not sure which is which.

Also known as 1080, the rat-poison.

 

[Solipsis]

Lol Nuke, the sarcasm is so cutting, its making my monitor bleed

A: F2 makes most things burn on contact.

B: surely you haven't forgotten about the toxicity of fluoroacetic acid/fluoroacetate salts, they get metabolised to fluorocitric acid, which can't be metabolised in the krebs cycle, nasty stuff, no antidote, and interestingly, its one of the very few and far between organofluorine compounds occuring in nature, produced by an S.african plant 'gifblaar' I think is the native name, or 'gifbol' not sure which is which.

Also known as 1080, the rat-poison.

So what? Not every "organofluorine" acts the same or similar, I think there is not even a remotely relevant metabolism aspect to 4-FA, though I heard 4-fluoro compounds can present some cardic problems... 4-FA is probably only slightly more physically stressing than normal amphetamine.

On new years eve I'm planning to attend a huge techno party, like I was planning on when I put an earlier post in this thread - I didn't go to the party that time though.
This time I already got the ticket, friends of mine are not really into (rare) hard drugs the way I am and are having a special time on MDMA (one of the first times for pretty much all). The party lasts for about 13 hours!
I'm thinking about taking about 100-130 mg of 4-FA at the start of the night, then hold a pill ready containing about 120 mg of MDMA plus 20-30 mg of MDEA (supposedly really modulating the roll!! legendary stuff).
Does anyone have any comments on this? What can I expect, anything to take into account?

 

[Ziquor]

So what? Not every "organofluorine" acts the same or similar, I think there is not even a remotely relevant metabolism aspect to 4-FA, though I heard 4-fluoro compounds can present some cardic problems... 4-FA is probably only slightly more physically stressing than normal amphetamine.

On new years eve I'm planning to attend a huge techno party, like I was planning on when I put an earlier post in this thread - I didn't go to the party that time though.
This time I already got the ticket, friends of mine are not really into (rare) hard drugs the way I am and are having a special time on MDMA (one of the first times for pretty much all). The party lasts for about 13 hours!
I'm thinking about taking about 100-130 mg of 4-FA at the start of the night, then hold a pill ready containing about 120 mg of MDMA plus 20-30 mg of MDEA (supposedly really modulating the roll!! legendary stuff).
Does anyone have any comments on this? What can I expect, anything to take into account?

4-FA seems to be a pretty novel stim. After reading the clinical studies I wouldn't be surprised if it didn't make it way to a clinical medicine someday (hey there's much worse out there). Many of the 3 & 4 substituted PEA's can have cardio-toxic effects which mainly stem from agonistic activity at the 5-HT2B receptors. 4-FA doesn't seem to have this property as it most closely seems to resemble amphetamine. Though 4-FA seems to be about 50-60% as potent mg for mg. 4-FA also doesn't seem to have the neurotoxicity issues that the 3,4-MD & other 4 substituted compounds have. There's a great study on erowid about it.

In two studies I've seen 4-FA was nearly identical to amphetamine in mechanism of action. The only differences were 4-FA released just slightly more serotonin than amp, and also the 4-FA released less norepinephrine - which is a good thing IMO - less stimulation & jittery sides. If it had a shorter mechanism of action it would be the ideal stim IMO.

 

[obscurus]

"However, the parent compound 4-fluoroamphetamine has been evaluated and compared to other halo amphetamines. While the 4-bromo and 4-chloro amphetamines significantly affect serotonin levels, 4-fluoramphetamine has been found to have minimal effect on 5HT, and contrary to the other halogens, levels are restored within days of use." -http://www.drugs-forum.com/forum/showpost.php?p=345415&postcount=10

Does minimal effect mean minimal serotonin release, or does it mean minimal damaging effects on the receptor itself?

I feel absolutely no comedown on this stuff. Seems much less harmful than cocaine and regular amphetamine.

 

[Ziquor]

"However, the parent compound 4-fluoroamphetamine has been evaluated and compared to other halo amphetamines. While the 4-bromo and 4-chloro amphetamines significantly affect serotonin levels, 4-fluoramphetamine has been found to have minimal effect on 5HT, and contrary to the other halogens, levels are restored within days of use." -http://www.drugs-forum.com/forum/showpost.php?p=345415&postcount=10

Does minimal effect mean minimal serotonin release, or does it mean minimal damaging effects on the receptor itself?

I feel absolutely no comedown on this stuff. Seems much less harmful than cocaine and regular amphetamine.

Both actually. The neurotoxicity for this compound in initial studies has been shown surprisingly low, similar to the plain old amphetamines. PEA's get each of their unique profiles mostly from their monoamine releasing/inhibiting ratios. The monoamine (Dopamine, Serotonin, & Norepinephine) releasing effects of 4-FA has been shown to be almost identical to amphetamine, only 4-FA released more serotonin (still not nearly as much as MDA, MDMA, MBDB etc.) and 4-FA has a slightly lower NE releasing effect.

Here is my aforementioned link - lot's of great info in this study:

http://www.erowid.org/archive/rhodium/pdf/4-fluoroamphetamine.pdf

 

[Tryptamite]

Penis shrinkage?

How does it combine with GBL?

 

[phatass]

read a TR about this, the person wasn't too impressed, said it was very similar to speed (amphetamine) just a LOT more expensive..

 

[Coolio]

After a few trials with it I've decided this chemical is horrible compared to amphetamine, MDMA, or methylone.

 

[ebola?]

>>
Both actually. The neurotoxicity for this compound in initial studies has been shown surprisingly low, similar to the plain old amphetamines. PEA's get each of their unique profiles mostly from their monoamine releasing/inhibiting ratios. The monoamine (Dopamine, Serotonin, & Norepinephine) releasing effects of 4-FA has been shown to be almost identical to amphetamine, only 4-FA released more serotonin (still not nearly as much as MDA, MDMA, MBDB etc.) and 4-FA has a slightly lower NE releasing effect.>>

One question comes to my mind:

Lets say that you have two hypothetical drugs, each inducing the same degree of monoamine release IN SUM. However, drug 1 releases a moderate amount of dopamine, a large amount of 5ht, and a moderate amount of NE, while drug 2 releases a large amount of dopamine, a moderate amount of 5ht, and a moderate amount of NE. Their durations are identical, as are the levels of compulsion to re-dose, as are the toxcicities of the metabolites.

Which would be more neurotoxic? What is the bottleneck in the pathological uptake of DA by SERT, the amount of intercellular dopamine or the number of SERT that have 'spat out' serotonin, leaving them open to reuptake of dopamine?

ebola

 

[I crash here]

Would this stuff be useful as a study aid? Perhaps in the low dose range, 30-50mg? Seeming as people say it is quite similar to regular amphetamine and that can be quite helpful as a study aid. Does this compound have a fiending effect, trying to chase the high?

 

[bob_arctor]

I crash here: I have no experience of it in lower doses (50-60 mg) other than as a good working addition to mingling or a night at the pubs - you are a bit more alert, but the full duration of the higher dosage isn't there really - but so couldn't say about how it would help focusing for study.

Can say though that neither lower, mid (75-125 mg) or full-on empathogenic party range (~200-250 mg) has left me fiending for more.

 

[fasteddie]

I have heard that 4-F MA is smoother than the unsubstituted compound, because it cannot be hydroxylated at the 4 position. The 4 OH compound is said to be nasty.

 

[shake]

this thread is OLD.

iam back in the dead

 

[Ne0]

How much fluoride 4-fluoroamphetamine contains if it does any? Since its fluoride derivative, I'd like to know how much I'm risking with this one. Fluoride is bad in high amounts and excessive use of fluoride can cause Skeletal fluorosis.

 

[pofacedhoe]

I am taking tramadol is it safe to combine 4floura stimulant with a dose of 100mg tram???Will the tramadol make the high more effective so able to use less of the stimulant?

4fmp may have maoi effects (dont know where i read that but it feels like it does. i took next day tramadol after 2ci 4fmp 4acodmt combo(which was amazing and on alcohol) , felt like too much serotonin, headache and overheating thought the weather temp increased by about 5 degrees that day over the previous with intense sunshine. no real mental down or comedown just mdma style rough edges to my body feel. was able to get up to meet a feck baddie with amazing sex ensuing(thought that could be the poppy laced cafe latte. no bad effect on appetite but i'm in a hypomanic episode at the moment and my appetite is beyond huge. i have three dinners each evening (because i'm lovely you see) and i cannot put weight on.

the combo was 45mg of 4fmp 3 mg of 4acodmt and 10mg 2ci.

very synergystic. felt like strong mda but much less rough bodyload and after effects. beautifull

 

[fasteddie]

How much fluoride 4-fluoroamphetamine contains if it does any? Since its fluoride derivative, I'd like to know how much I'm risking with this one. Fluoride is bad in high amounts and excessive use of fluoride can cause Skeletal fluorosis.

Answer: none. The F is covalently bonded to the phenyl group. It does not come off. I imagine that the drug is excreted unchanged.

 

[latac]

How doest 100-200mg of 4fa effects a mushroom trip?
example:
friday night - consuming 4fa
0-4 hours of sleep
saturday evening - shrooms

edit: it does not effect shrooms

 

[nuke]

So, I've found a study that in contrast to others does claim neurotoxic effect from 4-FA:

Effects of intraventricuear p-chloroamphetamine and its analogues on cerebral 5-HT
A. Shermana, E. M. Gála, R. W. Fuller* and B. B. Molloy*

a Neurochemical Research Laboratory, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA

* The Lilly Research Laboratories, Eli Lilly and Company., Indianapolis, Indiana, USA

Accepted 26 March 1975. Available online 6 November 2002.

A dose-response curve for serotonin (5-HT) depletion by intraventricularly administered p-chloroamphetamine was established along with its effect on the activity of tryptophan-5-hydroxylase. The effects of several analogues on cerebral 5-HT were assessed following their intraventricular administration. Changes in 5-HT were determined at various time intervals after administration of the analogues. The minimal intraventricular dose at which p-chloroamphetamine depressed 5-HT at six hr after injection was 200μg. Of the agents tested, only chloroamphetamine reduced both 5-HT and 5-hydroxyindoleacetic acid at six hours. p-Fluoroamphetamine and fenfluramine, like p-chloroamphetamine, produced a long-lasting depression of cerebral 5-HT levels. Intraventricularly injected p-chloroamphetamine reduced activity of tryptophan-5-hydroxylase with and without iprindole pretreatment, but had little effect on catecholamine levels. The results are compatible with the previous hypothesis that p-chloroamphetamine is converted to some metabolite responsible for the long-term neurotoxic effects.

However, I don't know the duration of times at which they were measuring and the wording is kind of strange. In other studies it's indicated that 4-FA reduces 5HT levels temporarily but they later regenerate.

 

[naginnudej]

So, I've found a study that in contrast to others does claim neurotoxic effect from 4-FA:


However, I don't know the duration of times at which they were measuring and the wording is kind of strange. In other studies it's indicated that 4-FA reduces 5HT levels temporarily but they later regenerate.

Interesting. Have any other interesting tidbits about this substance? Perhaps we should make a Big and Dandy and see if anyone can bring something to the table.

I'm seriously considering mixing this with MDAI for a nice MDMA substitute. Wonder how that would play out.