4DQSAR
Bluelighter
- Joined
- Feb 3, 2025
- Messages
- 6,305
Well, it's your body. If you are prepared to play the 'mystery powder game' then all I can say is good luck.
It just seems a bizarrely complex bioisostere of the ester function of methylphenidate when simply reversing that ester and producing levophacetoperane derivatives would be the much simpler option. It is a medicine, ring-substituted derivatives DO turn up in the literature therefore it's more of a known quantity.
I think THAT is the detail I find suspicious. Because levophacetoperane was only ever used medically in France, it's legal almost everywhere else and we have a lot of data showing that it's activity is very similar indeed to dexmethylphenidate, in double-blind studies the two were found to be equally effective and it's metabolism is well understood. It just appears someone went for an aromatic bioisostere as some sort of bizarre flex. Keeping it as safe, cheap and simple as possible to me would seem more rational. Ring-substituted drivatives have been studied so we at least have some data. If it reached animal models then it passed things like the Ames test.
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