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"3,4-methylenedioxy" analogue of propylhexedrine: a good idea?

Hammilton said:
Personally I love the shit out of propylhexedrine. A brand new sniffer, sniffed on fairly heavily for a few minutes is every bit as good as amphetamine. but I've always been odd about stimulant choices.
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sniff? you are supposed to either swallow the cotton inside the inhailer or do a simple extraction of the cotton. i don't think simply sniffing from the inhailer for a few minutes would work.
 
He responds to more sensible dosage-levels. Also, never swallow the cotton, as you risk impacted intestines.

i don't think so because the parent drug of MD-phenmetrazine is a better stimulant than methylone's. MD-phenmetrazine would probably be more likened to MDMA or MDA than methylone.
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Things are more complex than this. Look at the structure for phenmetrazine and how different it is from amphetamine. Why would we expect similar SAR?

ebola
 
We appreciate yer creativity and enthusiasm however as i said... There's a big difference between something being a stimulant and it being an entactogen/empathogen. It's not as simple as tacking a 4-x or 3,4-X onto a corresponding stimulant. Even if said stimulant resembles a phenethylamine somewhat it may not be enough, the SAR is alot trickier for serotogenic stims as opposed to just str8 stims. Just cuz the stim is more potent doesnt mean the addition of any alkyls are gonna make it serotogenic at all. I'm not trying to hamper your drive for theorizing the next MDMA or whatev but I might suggest reading up in these forums stims or whatevers of the future. Generally anything outside of a Phenethylamine probly wont work. aminoindans, phentermines, cathinones, and tranylcypromine are pretty much PEAs with slight tweaks. I think tetralines are the most different but still overlaps pretty well. Without some knowledge that the chemical class yer working has any affinity for 5HT yer just making uneducated guesses, thinking outside the box is one thing but don't get carried away
 
Can't believe this is still going

take an Organic Chem class, then maybe you can keep up with these guys..

ADD is hardcore shizz
 
Swerlz said:
Can't believe this is still going

take an Organic Chem class, then maybe you can keep up with these guys..

ADD is hardcore shizz
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I'm sure I have got burned at the stake for lesser offenses of chemwanking:\
 
this just hit me...

NONE of these stimulant/empathogen MDMA repacements are ever gonna get made. and even of they did, our old pals at the DEA would make them schedule 1 as soon as they hear about it. so i should just stick to MDMA because any of these "ideas" either won't work or become illegal like MDMA or MDA or any of the good stuff we know will work...

*as for this thread: abandon ship
 
swirls said:
Can't believe this is still going

take an Organic Chem class, then maybe you can keep up with these guys..
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I dunno, man. This guy's both enthusiastic but also willing to learn, even if that entails severe criticism of his own views. This is more than we can say for most here who aren't professionals in the field.

ebola
 
StaySedated said:
this just hit me...

NONE of these stimulant/empathogen MDMA repacements are ever gonna get made. and even of they did, our old pals at the DEA would make them schedule 1 as soon as they hear about it. so i should just stick to MDMA because any of these "ideas" either won't work or become illegal like MDMA or MDA or any of the good stuff we know will work...

*as for this thread: abandon ship
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oh no! he gave up. lol
Don't get frustrated, just get educated. The idea of coming up with new compounds isn't a lost cause. It's not just to stay a step ahead of the DEA, it's to learn more about SAR(and have fun doing it;) ), and maybe stumble upon something as good or better than MDMA/MDA. It's not hard to get these to b made if u learn chemistry or pay someone who knows chemistry to make it for u.
 
StaySedated said:
take a class? damn...

that sounds like a lot of work on my part.
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then maybe just listen to what they say...

when moderators here are telling you something listen to it (thats how i have learned a lot about things i only had a small understanding of before). these propylhexedrine threads feel like a bumble bee wacking a window over and over=D
 
^^ aye on the bumble bee analogy. Its funny over the years watching the repeated chem-wanking, lefetamine questions, BTCP questions, redundant 4 subs on the benzene ring, the 3,4 methylenedioxy bridge tacked on to whatever, etc etc.....:! On the good side, at least there is a lot more interest now than a few years ago....:D
 
How else does anyone think the vast majority of new drugs come about if not by a single structural idea? (excluding accidental discovery)
 
StaySedated said:
take a class? damn...

that sounds like a lot of work on my part.
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More fun than that is the fact that a year of Organic Chemistry will only give you a semblance of literacy about organic compounds and geometry. You have to do a lot more work than that to get anywhere with SAR based on "your intuition". There's a reason some of the more knowledgeable people here don't just freely dump all that they know for the public to look at. It takes a lot of thought and work to actually make educated decisions, and yet the "market" is mostly headed up by ignorant money-grabbers. If that isn't a way to quickly become disenchanted with the "community", then I don't know what is. We can only thank our respective deities that Shulgin still believed in the free spread of his information.
 
I don't think you could attatch a methylenedioxy to 3, and 4, or to any other part of the 'ring.' A benzyl ring is flat. The ring, on propylhexedrine is not flat, however. So, even if you could get in on there, the bond angles would produce a lot of strain. I don't think it would do what you're expecting. Interesting idea, though.

@stom10 Don't forget about Sasha's pal: David E. Nichols
 
I can't provide a reference because it links to a vendor site but it look like this compound is going to be available very soon. Any volunteers?
 
Silverfox said:
it look like this compound is going to be available very soon. Any volunteers?
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Translation: 'I want to try this but I'd rather someone else risk their live first.'

Why isn't there a rule against this - if there is why is it rarely enforced? This is nothing more than 'personal harm reduction'.

There is no necessity to announce the availability of this or any other compound. It's very simple; those interested will probably find it (or something representing it) on their own. Those who find it may attempt to acquire it. Those who do and consume it will probably report on bluelight, another forum or somewhere on the internet. Fortunately google will make locating information much easier so there is need to rush into the unknown.
 
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