2ce;4-ho-met cross tolerance?

[khaosddt]

Hi there, saturday i plan doing some 2ce in the morning, and then continue once the trip is over with some 4-ho-met at a rave party. So i was wondering if there is any cross tolerance between those chemicals, and if not should i do 2ce or 4-ho-met first.

 

[NeighborhoodThreat]

There should be (in theory) an amount of cross-tolerance between 2C-E and 4-HO-MET, as they are both psychedelics with action on the 5-HT (serotonin) receptor system, among others. I wanna say the only research in regards to psychedelic cross-tolerance is in regards to psychedelic mushrooms and LSD. Considering 4-HO-MET is an analog of psilocin its actions (I'm assuming here) are similar to that of psilocin.

There will be cross tolerance. It should be anything from unnoticeable to LSD-to-LSD tolerance (basically have to double or triple your dose if you take it a second time within 12-24 hours).

If you're experienced with 2C-E and 4-HO-MET then I recommend lowering your dose of whichever chemical you plan on taking first so you don't have to increase the dose of the second one. If you want to play it completely safe then skip the 2C-E but I don't see any problems with cross-fading between the 2C-E in the morning and the 4-HO-MET at the party, just make sure you take the usual harm reduction measures as that's a lot of tripping for one day