Hello all, so I decided to try 2C-I this past week (dose was about 15mg). About 2 hours into the trip I had a very worrisome episode and I figured people should hear about this. I had sudden onset of constant, pressure-like left axillary, neck, and chest pain. Now, being a medical student with extensive background in emergency medicine I immediately thought about what it could be. I've seen this in hundreds of patients and the condition that fits most closely with my symptoms is anginal pain due to temporary ischemia of myocardial tissue. Being only 27 years old, I highly doubt that my coronary arteries are significantly obstructed by plaque. So the only reasonable explanation is an episode of acute coronary vasospasm, or an actual myocardial spasm. I did thump my chest several times with my fist because I was so worried, the logic being that if you have an embolus lodged in a coronary artery (or pulmonary artery), the shock can dislodge it before ischemia occurs. Or, if you have vasospasm, the kinetic shock may dislodge the agonist (in this case 2c-i) from receptors long enough for the spasm to reverse.
In any event, it was a scary episode. I've been doing some reading and it appears 5HT2b is heavily expressed in cardiac tissue. I wonder if there is a way to prevent this kind of thing from happening, perhaps an antagonist of some kind, but would that nullify other desirable effects? Basically I am worried that an older person, perhaps with a less healthy heart, a smoker, or more coronary occlusion than myself, could find themselves in a life threatening situation after taking a 2C-x.
In any event, it was a scary episode. I've been doing some reading and it appears 5HT2b is heavily expressed in cardiac tissue. I wonder if there is a way to prevent this kind of thing from happening, perhaps an antagonist of some kind, but would that nullify other desirable effects? Basically I am worried that an older person, perhaps with a less healthy heart, a smoker, or more coronary occlusion than myself, could find themselves in a life threatening situation after taking a 2C-x.
