Just rail it all up the 2cx and the 4 MMC. Expect burning but this is not so bad compared to say Ethylphenidate. Kind of like snorting mustard with the 2c's and some other mescaline analogues ie allyescaline etc. Maybe bomb 50 mg of 4 MMC 20-30 minutes prior to snorting whatever the dose of 4MMC and 2cx is. Pain is only 5 minutes maybe 10 max although this ROA will hit you like a brick. Then redose oral 4 MMC every 3 hours or so intra-nasal every 1-2 hours with a lower dose than oral. Depending on the 2c in question I'd redose 2cb at 3-4 hours intra-nasal and 2cd. 2cc say 5-6 hours and the rest I'd probably not bother snorting as they last a while and I'd mix any subsequent doses of 2ce/2ci etc in a drink as your already there. I dislike 2cp so I'd say avoid this one just don't enjoy it and get some sketchy feelings with my heart etc.
This combination (2cx 4MMC) is quite enjoyable indeed if you dose correctly and it's also fairly safe so enjoy

! For HR and myself I keep a few benzo's on hand but this combination say 2cb and 4 MMC is quite safe and nothing compared to some other combinations (MPA and MDPV fucking scary). Also dissociative drugs and psychedelics can cause serotonin syndrome so be careful experimenting with these. I'd probably do 15 mg 2ci with 5 mg diazepam as 2ci gives me some muscle cramps and benzo's really help. Some suggest magnesium but this won't help heart rate. Added to 75 mg oral 4 MMC and a line (with the 2ci/2cb/2cwhatever mixed into it) of say 50 mg 4 MMC 30 minutes after the oral dose. At some point I'd take a small oral dose of benzo's if I felt the need, safety first. Then every 2-3 hours another bump of 4 MMC or slightly larger oral dose. Don't overdo it I'd max out at say 250-300 mg 4 MMC over several hours. You can have an awful comedown that is super depressing from 4 MMC if you overdo it. Also 2-3 x 20 mg doses of 2cb one intra-nasal and one/two oral would be the maximum 2c dose. You can go higher with 2cd but if you feel your heart pounding or ringing in your ears it's time for a benzo and nothing more!
I'd not use Etoh (booze) it's a diuretic and a mild vaso dilator however excessive consumption has the opposite effect and it also interacts with the liver and kidneys breaking down the 4 MMC and 2cx. 4 MMC is a diuretic in itself as are most stimulant drugs hence why you need to pee more frequently when on said substances. Some people are different however and may retain fluid (like the difficulty peeing on MDMA as an example) I don't find this with the 2c's or 4 MMC but everyone is different so possibly have a trial run of say 50 mg 4MMC and 15 mg 2ci as a one off one day and assess your subjective reactions to the combination before going higher.
BTW 40 mg 2ce is mind fuck territory be sure to have at least 2-4 mg xanax on hand. Oh and it was very pure 2ce BTW always be cautious as you can have more but if you have to much you can't take it away. I have lots of experience with 2cx's in combination with MANY different substances, Hell I have many experiences with psychedelic combinations of tryptamines, PEA's, dissociatives usually say a PEA and dissociative or tryptamine and PEA or all three or stimulants with one or more. I must urge caution however with higher doses and ALWAYS have a benzo handy this will lower pulse rate, reduce vasoconstriction and anxiety. 80 mg MXE and 40 mg 2ci was a profound experience but not one for someone unprepared for that level of psychedelic insanity, also no benzo's were needed for that trip.