I'm a big fan of nicely synergistic psychedelic combinations, but I would not mess with 2C-T-2 combinations after a particularly bad experience mixing it with mushrooms. I one suffered rather dramatic temperature fluctuation where I'd feel overly hot one moment then shortly thereafter shivering cold. I was very, very close to asking my partner to take me to the ER that night for a couple hours. I also was suffering from a sensation of increasing throat constriction, panic and increased heart rate.
I'd used the exact same batch of 2C-T-2 several times prior to that, at higher doses, without any negative effects (same thing with the mushrooms which came from the same substrate as other mushrooms I'd been eating around that time). I don't recall the dosage amount of the two substances at the time, but it's in a trip report on erowid called mushroom combinations by CJ's Sock if you want more detail.