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2C-P's pain killing effects, "numbing", really good, whats the mechanism?

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yaesutom

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I've noticed for a couple years now, specifically 2C-P, has this ability to kill pain, really fucking well, and it feels nothing like an opiate, no euphoria etc, but.. well the shit works!

I took 12mg earlier (have not taken this stuff in a long time) and noticed what i've noticed on all over lower doses i've taken before of this. My back doesn't ache like normal. When I purposely inflict pain (pinching real hard on different parts of my skin or whatever) its like its there but.. "numbed". Distant. Really it seems like it actually does "reduce pain" more than any opiate ever did to me, with no euphoria or anything else, its just.. reduced.

I think i've noticed this on 2C-D also, once when I took it a couple years ago when my back ached i thought "oh, my back doesn't hurt anymore" and the same numbing of myself pinching my skin.

I wonder how this works? I mean its really damn good, don't know how else to explain it other than an opiate pain killer without any side effects (euphoria or whatever).

If this property could be used, and the molecule(s) modified to abolish psychedelic activity etc, i dunno.. there's something going on here thats killing pain really good, and its not opiate based.
 
These seem potentially related:


http://www.erowid.org/library/books_online/pihkal/pihkal018.shtml


Clin J Pain. 2003 Jul-Aug;19(4):276-9.

"Serotonin and experimental pain in healthy young volunteers."

Pickering G, Januel F, Dubray C, Eschalier A.

OBJECTIVE: The role of serotonin in the modulation of nociceptive input has been widely studied, and a link between serum serotonin (S-5HT) and pain thresholds elicited in patients with chronic painful pathologies has been shown. In the light of contradictory concepts on pain message modulation by S-5HT, this study tries to define whether S-5HT displays a nociceptive or antinociceptive role in experimental pain evaluation in healthy volunteers.

DESIGN: In 20 healthy young volunteers, 10 men and 10 women (21 +/- 2 years old), blood serotonin measurements were made, pressure pain thresholds was determined, and statistical analysis was performed.

RESULTS: This study showed a significant negative correlation of total blood serotonin with experimental pain detection threshold (P < 0.05, r = 0.444), but not with pain tolerance, while sex-related correlations of serotonin and thresholds were not significant. Lower serotonin concentration (P = 0.02), higher pain threshold (P < 0.01), and higher pain tolerance (P = 0.02) in men than in women were observed. CONCLUSION: Low pain detection thresholds may be explained by a peripheral nociceptive effect of serotonin. Pain tolerance does not, however, encompass a similar pattern of serotoninergic involvement in pain control and may include other components that remain to be elucidated. These results call for further studies on a larger population.
 
Cant say ever noticed this with any of the 2c's (although i havent checked) but MDMA defintely kills all pain for me.
 
There is an analgesic that has a 4-bromophenyl aromatic ring pattern. It is extremely potent too from what I gather but it not really very well recognized. Like I said before, do background searches on Daniel Lednicer for details.
 
Quite a few years back, I was self medicating for severe back pain, and I accidentally took 120mg MDA when I meant to take 20mg Diazepam (Valium) (kids, keep all medications plainly labeled and don't mix different medications in the same bottle). The MDA actually worked better than the Diazepam, although I layed still the entire time for fear of messing up my back even worse and not knowing it until I came down.
 
Lots of possibile spinal mechanisms... serotonin receptors, adrenoreceptors... *shrug*
 
All sorts of things. Amphetamine (in trials) was found to be only marginally less potent in analgesic effect to morphine. This resulted in clinical trials od 2-aminoindan as a potential new analgesic. It was dropped from trials when it was found to produce 'an unacceptable degree of CNS stimulation'

2-aminoindan (2-AI) has occasionally appeared on the RC market as a short acting, amphetamine-like drug. This extends further to ring substituted aminoindans; 5,6-methylenedioxy-2-aminoindan is described as a non-neurotoxic serotonogic agent - basically it's a cyclic analogue of MDA
 
Noradrenaline and serotonin release by amphetamine would be analgesic, after all nitrous is analgesic via spinal alpha adrenoreceptors.
 
Yeah 2C-P , dunno, certainly feels like a "new" kind of analgesic effect, not from noticeable "stimulation" really. I've noticed this ever since the first time I tried it, only like 1-2mg..

Maybe i'll have to test it out again at that level, not to "trip" but to see if it has the same pain numbing effects. Really ibuprofin kills a backache way better than opiates for me, and however this 2C-P works.. well it works :).
 
Aldous Huxley, one of the first to explore psychedelics in the 50s, already noticed their strong analgesic effect and advocated their use in dying people not only for the spiritual experience, but also for pain relief.
 
I've experienced this with mushrooms as well. Even with very low doses, not even doses which should trip you out. Just a little movement in mindspace.
 
yaesutom said:
Yeah 2C-P , dunno, certainly feels like a "new" kind of analgesic effect, not from noticeable "stimulation" really. I've noticed this ever since the first time I tried it, only like 1-2mg..

Maybe i'll have to test it out again at that level, not to "trip" but to see if it has the same pain numbing effects. Really ibuprofin kills a backache way better than opiates for me, and however this 2C-P works.. well it works :).
Click to expand...

ther is something different about 2c-p - as a trip I thought it was v good - ahhh memories eh?

I dunno bout painkiller but it's interesting if it is coz it lasts long so that is long pain relief - is teh effects mor with 2c-p then d or mor reliable or what?
 
Yeah I noticed it more with 2c-p than anything else really, I remember even low doses.. like 1mg, but i guess i'd have to test it again really.

Honestly, few nights ago me and a bunch of friends i got out my baggie of morphine sulphate and we snorted a bunch up, sure i was high.. but, i still had a fucking backache! WTF?? Ibuprofen works better for that than opiates - for me :). Seems like the morphine 'buzz', might make me not 'give a shit' moreso than actually killing pain, whatever 2C-P does actually does kill pain, I pinched myself while high on morphine and felt it, felt the same except I had a buzz going..
 
I've read that it was used/trialled with terminal cancer patients(LSD not 2cp i believe) back in the early sixtiesish and it was reckoned to be more effective than traditional analgesia(morphine etc).
zophen.
 
Does the analgetic effect have anything to do with the fact that 2c-p is hypnotic/sedative?
 
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