2c-i and serotonin levels

[dalek1983]

does 2c-i affect serotonin levels the way mdma does

 

[Mr Blonde]

It's more likely to have serotonin agonist effects rather then increasing levels of serotonin; MDMA has some action like this but mainly it works by releasing serotonin from neuronal vesicles.

Questions about psychedelic drugs belong in the forum Psychedelic Drugs... uh... yeah.

OD===>PD

 

[dalek1983]

is there any likely cross-tolerance between the two? would there be any depletion of serotonin from 2c-i

 

[any major dude]

i would say cross tolerance is unlikely, but I'd rather combine the two than do them on separate days close together... 2c-i won't deplete serotonin. You might have a diminished 2c-i experience within 3 days after mdma, but that would likely be more a result of the physical crash, dehydration, and general malaise that mdma can cause than an actual cross tolerance.

 

[dalek1983]

^^^^^^^^^^
thanks for that, that clears thing up for me

 

[muie]

In short 2c-i does affect seratonin levels but definatley no where near as much as say MDMA or mephedrone, methylone kind of drugs. I feel that I get a mood boost from it a day or two after the experience but that afterwards I feel a bit down, however I also have been doing a lot of MDMA for about a year.

 

[swilow]

I wonder if the agonism of 2C-I and the like displaces serotonin, leading to increased concentrations in some regions of the brain?

 

[avcpl]

So just to be clear....2C-I use should not have any effect on a subsequent mdma roll...correct?

 

[solistus]

2C-I works by the same mechanism as other psychedelics like acid and mushrooms, and I'm not aware of any evidence that it's a serotonin releaser or uptake inhibitor or anything like that. Tripping on 2C-I shouldn't disrupt your brain's serotonin levels. Some people find psychedelics less intense for a while *after* an MDMA experience, but doing them in the other order (2CI, then MDMA) shouldn't produce any major cross-tolerance.

I've never combined these two specifically, but 2C-E and MDMA was pretty a spectacular flip. I have used 2C-I multiple times a week for a couple weeks at a time before and, while tolerance built up and made the peaks less intense, I didn't notice any long-term serotonin depletion, and I'm pretty sure I took molly at least once during that 2C binge and had a good roll.

 

[avcpl]

thanks so much that is very helpful!