Phenethylamines [2C-E Subthread] 2C-E Dosage and Methods of Administration

[Newbierock]

Not everyone enjoys shoving chemicals up the ass. And if your going to be like that rectal is a waste, you should IV and not waste any drug.

 

[Erebus-]

I'm not suggesting shoving up the butt, but rectal increases intensity, it is not a waste. Intravenous is supposed to cause very painful heart palpitations.

 

[zerograv]

anyone find lower doses of 2ce to be unpleasant?
a few days ago i did somewhere between 8mg-12mg. i had never taken a dose that low. i usually take between 20mg-30mg. but that low dose i found to be absolutely awful. i never really blasted off, or received any visuals, but instead got an unpleasant body high. and extreme nausea.

idk, i thought it may have been bunk, but i haven't ever gotten bunk shit before. so idk.

 

[Xorkoth]

Actually I find low doses of 2C-E to usually be quite pleasant, whereas high doses tend to feel kind of mechanical and cold. I once had a low dose experience that was pretty unpleasant though. Really, 2C-E feels a bit different to be every time I take it. It's a versatile chemical.

 

[stillmind]

dosage and roi

I know there are no concrete answers, but I'd appreciate some informed opinions:

I typically have a massive psychedelic tolerance (which I attribute to having been on SSRIs for over a decade, up until a year ago). I've tried 2c-e three times.

First time 14mg oral, and absolutely no effects other than slight body buzz and mild visual enhancement.

First time 20mg oral, and basically same as 14mg. 4 hours in I insufflated 3-4mg, and the trip suddenly kicked in, though it didn't last long.

Second time was 25mg oral, and effects were only slightly stronger than with the 20mg. Once again, at 4 hours I insufflated a supplement - in this case 5-6mg. This time, the trip got overwhelmingly strong within a few minutes, I had a thought I found very threatening, and I had my first true experience of psychedelic panic. Though once again the heightened effects died down fairly soon, a residual terror stayed with me for two months.

After some positive, lower dose LSD experiences, I want to try 2C-E again. It seems like oral just doesn't work for me, for whatever reason. I see two options.

I suppose I could try increasing the oral dose yet again, probably to 35mg. Yes, I'm aware of the dose-response curve, but if 25mg does virtually nothing, I think a big step up makes sense.

Or I could try just insufflated, despite the vicous nasal burn. But I'm really at a loss as to the dose. I'm wondering how much of the effects I got after insufflating before were due to the synergy between the oral and insufflated, and how much was insufflated alone. Ie, would 5mg insufflated alone produce the same intense effects I had from 25mg oral + 5 insufflated. I'm sure most people would dismiss that possibility, but keep in mind I really had almost no effects from the 25mg alone.

I'm also wondering, how long does an insufflated dose take to peak? I"m thinking I might start with 8mg insufflated, and then supplement if necessary, but I'm wondering how long I should give it to fully kick in.

Any insights much appreciated.

 

[retired_chemist]

I prefer insufflation of 2C-E personally, usually in the 8-14 mg range. I find the come up is rapid - within 15 minutes. As far as "peaking" I would say I am really peaking for 2-3 hours after that but insufflation does not seem to shorten the trip substantially. I can still feel definite effects at 8 hours, then they begin to drop off after that, but sleep is difficult without a benzo.

I do not take SSRIs and do psychedelics too infrequently to experience refractory effects.

 

[Erebus-]

I prefer insufflation of 2C-E personally, usually in the 8-14 mg range. I find the come up is rapid - within 15 minutes. As far as "peaking" I would say I am really peaking for 2-3 hours after that but insufflation does not seem to shorten the trip substantially. I can still feel definite effects at 8 hours, then they begin to drop off after that, but sleep is difficult without a benzo.

I do not take SSRIs and do psychedelics too infrequently to experience refractory effects.

Do you find insufflating it painful? I have read that it was, but then I read posts like this and wonder. The come up for 2C-E orally is too long, and sometimes I don't have 12 hours to spare, and I'm running out of my stash.

 

[retired_chemist]

Do you find insufflating it painful? I have read that it was, but then I read posts like this and wonder. The come up for 2C-E orally is too long, and sometimes I don't have 12 hours to spare, and I'm running out of my stash.

Well it is not anything smooth like a good line of coke or meth, but we are talking about 8-14 mg here - not exactly a rail, just a little bump. I blow my nose out good (well actually I perform thorough housekeeping, lol, gross I know) so I'm good and clean. Then I sniff a a tiny little water and blow it out and dry my face off. Not enough to have water drip, just get the membranes a little layer of dampness.

Then when I am clean, relatively dry but a little damp on the membranes, I bump it up and it shoots right in.

Does it burn? Yes. Definitely. Does it burn like hell, hell is relative. The pain passes in minutes.

It is not pleasant, but the difference in effects for me personally makes it more than worthwhile. Is it as bad as everyone says? Well as far as I can see everyone describes the pain as so bad it sounds more like you were having an anal pear opened, or your nuts slowly vised.

It's burns yet, but not THAT bad.

I like it for several reasons. Mainly the rapid blast off alters the course of the whole trip. And it conserves my stash. As far as length - I have not experienced the drastically shortened trip others describe. It still last hours. My opinion is that it may be a couple hours at most shorter, probably due to a lower total dosage than insufflation itself.

 

[stillmind]

Thanks Retired Chemist, that's very helpful. So basically, you're saying that after 15 minutes, that's as intense as it's going to get?

Meaning, that I could conceivably start with say, 8mg, wait 15 or 20 minutes, and if I'm not where I want to be could supplement with a few more mgs? Have you ever tried titrating up your dose like this?

 

[retired_chemist]

Thanks Retired Chemist, that's very helpful. So basically, you're saying that after 15 minutes, that's as intense as it's going to get?

Meaning, that I could conceivably start with say, 8mg, wait 15 or 20 minutes, and if I'm not where I want to be could supplement with a few more mgs? Have you ever tried titrating up your dose like this?

Hmm. Not exactly. I'm saying when I insufflate the come up starts on very fast and very intense. You feel yourself being ripped through the mind's time space continuum. It's a period of wow I'm really taking off hard, and I think it accelerates the nausea effect which I often feel to where if it;s gonna happen it will happen soon.

Over a period of the maybe say the next hour you find yourself increasingly less overwhelmed by the intensity of the initial blastoff and settling into a strong continuous smooth peak.

I would suggest waiting maybe an hour for the full "equilibrium" effects that will be with you for the remainder of the trip.

I like doing it this way not because I find the rapid intense immediate effects enjoyable, but it compresses an intense disorientation into a short time which seems to "clear my psyche" and lead me smoothly into the period where the effects plane out. Also the nausea effect. If I'm gonna get it, I like to get it done. Oral doses tend to give me somewhat milder, but also slower onset and longer lasting feelings of unwellness.

Also I am not a big fan of interval titration anyway. I think it is better to start at a lower dose, see how it is, wait until the next time, not the next time interval, and adjust over a period of separate experiences until you find the starting point you like.

But that is me. 2C-E seems to be highly variable amongst individuals, so I can only say this is how and why I like to do it for myself. YMMV.

 

[fastandbulbous]

Or I could try just insufflated, despite the vicous nasal burn

Why do people insist on the 'red hot poker up the nose' response to snorting 2C-x compounds when dissolving it in a little water and squirting it where the sun doesn't shine (plugging it) is pretty much pain free and has the same onset chronology and increase in potency over oral admin that snorting has?

Anybody giving a homophobic reason for avoiding rectal admin, rather than a valid one such as piles or an anal fissure is most probably deserving of the eye watering pain for their bigotry...

 

[lastnight]

^^ i don't understand it, either.

it drastically reduces the body load in me,
takes half the material,
and is completely nausea free.

the high feels deeper to me, too.

 

[butane]

stillmind:

I've heard very different reports from insufflating 2C-E. It seems as though the pain response varies widely from person to person. To me, it feels like getting shot in the face, but to my good friend J it doesn't hurt at all. In fact, he exclusively uses his 2C-E by snorting it. If snorting it works well for you, go for it.

However, you have a few other options that you may wish to consider. The first and probably best option is rectal administration. There's no need to be grossed out by it, everybody has an asshole and yeah it stinks, but it's very useful in this kind of situation. It's as potent as snorting with the duration of oral dosing, and because of this it's a FANTASTIC way to make your stash last longer. Another option you may wish to consider is intramuscular injection. Again you get the potency of snorting, and the duration is somewhere in between snorting and plugging. It doesn't really hurt. However, if you're afraid of needles this may not be the way to go.

 

[retired_chemist]

I'm sure to some people plugging is some sort of taboo.

For me personally the only time I get nervous about my rectum is when I'm in the doctor's office and hear the sound of the latex glove "pop".

Some people just like the ritual of snorting drugs, and pain avoidance is not really a factor.

 

[ompa86]

Yeah, it seems that some people have really big problems with snorting 2c- chemicals, but me for example, -I do not experience any big pain...

Though I prefer to take 2c-e the oral route. I don't like the quick onset when snorting, I get confused and it all winds up at a fast speed. The intensity of the trip also seems to drop of after some time, at then continue at a milder level...

With oral ingestion you get a smooth and long come-up (first effects at around 60min), the trip lasts longer and the intensity of the trip gradually fades and you are also spared the pain when snorting.
For me an oral 2c-e trip lasts around 7hours or so...

 

[stillmind]

Why do people insist on the 'red hot poker up the nose' response to snorting 2C-x compounds when dissolving it in a little water and squirting it where the sun doesn't shine (plugging it) is pretty much pain free and has the same onset chronology and increase in potency over oral admin that snorting has?

Anybody giving a homophobic reason for avoiding rectal admin, rather than a valid one such as piles or an anal fissure is most probably deserving of the eye watering pain for their bigotry...

The only reason I hadn't given much consideration to rectal is that I know nasal works, so I don't want to throw another unknown variable into the mix. But I'm not averse to trying it.

Has anyone tried both nasal and rectal admin, and if so, are dosages equivalent?

Also, is it really necessary to dissolve in water? I don't have a syringe, just gelcaps.

 

[retired_chemist]

Anybody giving a homophobic reason for avoiding rectal admin, rather than a valid one such as piles or an anal fissure is most probably deserving of the eye watering pain for their bigotry...

That might be a little harsh. I can see applying bigotry to a person who hates gay people because of an ideology.

But there are some people that are homophobic because of their own insecurities about their heterosexuality. Fearful and insecurity are probably more appropriate adjectives to the explanation of their behavior. They just need to get past all that embrace their inner gay and decide which side of the fence they are happier on.

 

[butane]

Sticking a loaded gel cap up your butt works just fine; I've done it plenty of times. It takes a while longer to kick in, but whatever.

 

[stillmind]

rectal vs nasal

This is sort of a repost of my previous question, sorry. but really hoping to get an answer.

Has anyone tried both rectal and nasal administration of 2c-e?

If so, how do they compare, especially in regards to dose and timeline?

Thanks -s/m

 

[Mr Blonde]

Why do people insist on the 'red hot poker up the nose' response to snorting 2C-x compounds when dissolving it in a little water and squirting it where the sun doesn't shine (plugging it) is pretty much pain free and has the same onset chronology and increase in potency over oral admin that snorting has?

Have you snorted 2C-E before? I have, and found it to be a lesser experience... more shallow I guess. I'm interested in trying rectal, but would just want to make sure I don't 'lose' some of the magic like I did nasally.

If so, how do they compare, especially in regards to dose and timeline?

Read F&B's post (or just read the portion I quoted above), apparently the same in terms of dosing and timeline.