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2C-E + Dissociatives

15mg 2C-E and 30-40mg MXE mixed and sniffed together in the same line is one of my favorites. No nausea, the fluffy 2C-E mixes in nice so it hits harder and no big sticky flakes just sitting and burning in the nose, MXE keeps the panic of a rapid accent at bay, and a low dose will get me a big trip.
It's beautiful.
 
Hard head with most 2C-X and some 4-subs, normal with the rest.
The problem for me with snorting 2C-E by itself is my batch is all super fluffy and sticky, so it sticks to itself and gets clumpy, like trying to snort painful, barely psychedelic lint. Mixed with a crystalline substance the mechanics work just fine. Still if the mix was not MXE it would be more like 30-40mgs to get to a high 2 low 3, with a rough come up and worse mind state throughout.
 
All 2ce I've procured had those characteristics.
Makes it very hard to deal with, and when a clump goes up my nose it feels like it explodes in my sinuses and feels like someone punched me inside my nose.
I'm never snorting 2ce again, oral is plenty powerful plus it lasts longer.
 
In my experience 2CE plus Nitrous or Ketamine was fucking mind blowing. I loved it. I miss 2CE, shame I ran out.
 
Elaborate?

Mixing phenethylamines with DXM is notorious for having unsafe and/or unpleasant side effects. Phenthylamines, like 2c-e share some pharmacological similarities with amphetamines, and are capable of producing cardiovascular anomalies and dangers, as well as running a general risk for serotonin syndrome when combined with DXM. Of course phenethylamines differ from each other in a variety of ways, and the risk profile for each will vary similarly. Despite that, the potential for danger is quite considerable when mixed with DXM, especially when the heart is concerned. Discretion should always be used when taking research compounds, which generally have little to no human or animal testing whatsoever, ESPECIALLY in combination with something like DXM, which itself has such a varied and often unpredictable pharmacological profile (particularly in combination with other drugs)

Edit: This is more so to do with DXM and 2c-e, not dissociatives in general.
 
As far as I know 2c-e does not cause an increase in synaptic serotonin, or not to an amount which could cause serotonin syndrome (I forgot who posted a graph showing that even LSD raises serotonin levels a bit, but to a negligible degree and the value was actually within the margin of error range) and as far as I know PCP does not affect the serotonin system in the way PCP or its analogues do.
Compared with the other phenethylamines, 2c-e is generally regarded as being of the safest physiologically.
 
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