I don't fully agree with Anon.. but on the other hand, if you need an idiots guide, then yeah you probably shouldn't be handling the powder.
There is a lot of info on this throughout the NBOMe threads and even one that talks about it specifically IIRC. You'll even come across a post of mine where I clarified how I was going to handle it based on what I had read, just to make sure I was doing everything right.
That said, a lot of people warned me of the intensity of snorting 25i.. I "titrated" from a low dose of 400ug just to feel it out, and the body 'load' was intense but managable, I felt like it was like I had popped a molly or two (gotta keep it real with the slang u no). So a week later I bumped to 800ug. The body rush load was almost too overwhelming.. visually shit went pretty bananas but I was still all there and handling it with ease, but my body was just bonkers for the first hour or so, at one point it felt like eveyr muscle fiber in my body was contracting, almost like a seizure, and its from this that I can see how people end up having seizures on this shit.. could be related could not be..
Anyway yeah, if you really need your hand held, grab some blotters my friend.