i can't seem to find any solid evidence that it doesn't work orally other than anecdotal reports from users. If it does work orally then a significantly larger dose must be used but it's just a waste of material when sublingual works fine. check out the big and dandy thread for 25i. ROA are discussed quite a bit; the general consensus is to either use the sublingual/buccal (upper gums and lip) method or to snort it.