25i-NBOMe and 6-APB

[Crashing]

I was wondering if anyone knows or has experience off the top of their head with taking 6-APB and 25i-NBOMe within the same week. Wondering about cross tolerance. I have like a 10 day span coming up to me which i have the opportunity to get crazy, and it's a tough decision on how i want to really spend my time. I really want to use both but not if one would negate the other.

I know with LSD and MDMA there is cross tolerance but i wouldn't think the comparison to be the same. Either way I would probably want to take the 25i prior to the 6-APB because I think the apb releases more serotonin.

Anyone tried using Stimulant Empathogens and Psychedelic Phenethylamines back to back or within the same week?

 

[lamanogaucha]

They both cause cross-tolerance. 25I-NBOMe is worse in this regard than 6-APB, so you should take the latter prior to the former. Wait at least one week between trials.

 

[Crashing]

Yeah i guess the 25i is probably best taken after the 6-apb now that i'm looking at the pharmacology more closely.

 

[Dmytry]

taking the 25i after the 6-apb would be the most effective in terms of binding affinities and downregulation, but i personally prefer to trip before i roll. i like having serotonin while im tripping.
ive taken doc (within an order of magnitude of potency of 25x) for a few days before, and the day of taking 6-apb and had an amazing roll. it kind of cancelled out the trippy feeling towards the end of the 6-apb and allowed me to sleep much sooner/easier

 

[Crashing]

taking the 25i after the 6-apb would be the most effective in terms of binding affinities and downregulation, but i personally prefer to trip before i roll. i like having serotonin while im tripping.
ive taken doc (within an order of magnitude of potency of 25x) for a few days before, and the day of taking 6-apb and had an amazing roll. it kind of cancelled out the trippy feeling towards the end of the 6-apb and allowed me to sleep much sooner/easier

That's what i was originally intending because rolling is generally more hard and fast in terms of effects, whereas tripping is more of a grab bag. The dosages im looking at are 1000ug 25i and 125mg of 6apb. Either way would probably work out because i have been generally healthy and free of substances for a good while so I think my body will recover quickly from each.

I have never experienced either substance, but any other trip or roll i have ever taken has never resulted in a 'day after' effect for me, other than maybe feeling slightly 'out of it' but it wasn't negative, i just usually feel tired as to be expected.

A tie breaker would be nice at this point.