25i (2ci NBOMe) and Selegeline

[Synaptic Gap]

I have been on 5mg Selegeline a day for about 3 weeks and have some 25i (2CI NBOMe) on the way in a few days. I know it is probably not safe to combine them and found not 1 single report on the combination in days of researching on the net. I was wondering if anyone has any info at all on this combination.

Could stopping the Selegeline for 5 days reduce the risk much? How great of a potentiation factor might there be?

Has anyone at all tried this or know anyone who has tried it?


On a side note, Last weekend i did about 400mg mescaline and did not have any kind of bad reaction. It actually increased the euphoria and duration quite a bit but the visuals were not intensified. I bring this up because Mescaline is also a phenethylamine and I had no problem with combining it with Selegeline.

 

[Mugz]

You can speak as though you are yourself on this forum, just say I and me instead of your friends ferret, it makes things so much easier to read. Also, you will probably get more answers to this question in the psychedelic drugs forum than this one.

Welcome to bluelight though Nice username too.

 

[Synaptic Gap]

Thanks for the advice and compliment. I Just registered and still learning the layout. How can I move the thread?

 

[effie]

Hi there, welcome to BL and BDD

As Mugzy said we don't use "swim" or "my pet ferret" or any such variation here - it doesn't protect you at all and makes your posts difficult to read. Take a look at the BLUA and the guidelines for any forum you post in. I would appreciate it if you could edit your post

Selegeline is a MAOI (selective for -B at low doses but non-selective at high doses; -B metabolises dopamine and phenethylamines) so I would be very cautious about mixing it with 25I-NBOMe as that is a phenethylamine. Selegiline's duration of action depends on the time it takes to regenerate MAO-B; I believe this can take up to a few weeks.. I admit I don't know much about the pharmacology of this though. At higher doses (>10mg/day) it also inhibits MAO-A which means you need to take great precautions to avoid anything serotonergic or food containing tyramine.

I'm going to move this over to Psychedelic Drugs as they deal with questions on psychedelic drugs such as the NBOMe series, hope that's okay.

BDD > PD

 

[Synaptic Gap]

Sorry about that I thought it was just "SWIM" that was bad. It has been edited. Thank you for the advice and for moving it to the correct forum.

 

[psood0nym]

I would definitely have him hold off for at least two weeks to give his brain time to create dopamine that's not bound to selegeline, probably longer. Selegeline strongly potentiates 2C-x drugs, and with 25I I don't think there's even anecdotes about how much it might be potentiated by selegeline. Also, due to it's extremely high potency accurate dosing always demands at least a little faith and so adding an unknown amount of potentiation and potentially other interactions on top of that the uncertainty and potential risk is high.

Hell, I once took a couple hundred mg doses of regular phenethylamine with selegiline and after the second dose my skin got blotchy and I could feel my pulse in my face. If I had taken another 100 on top I'd probably have had a hypertensive crisis. It's potentially quite dangerous in combination with a lot. I wouldn't want that question mark hanging over my head before I dosed 25I. Even if there's no strong interaction he'd be going into it with a ton of anxiety just from not knowing, so bad trip risk is high either way.

 

[Synaptic Gap]

I have tried PEA(regular phenethylamine) up to 400mg while on 5mg/day selegeline a couple of times and didnt have any bad reaction. It felt like I was on MDMA for about an hour.

 

[psood0nym]

I have tried PEA(regular phenethylamine) up to 400mg while on 5mg/day selegeline a couple of times and didnt have any bad reaction. It felt like I was on MDMA for about an hour.

Ok. I did. Others have ended up going to the hospital. You didn't. That doesn't mean the effects of combining it with 25I are any less uncertain. The subjective effects of the 25Xs bear little resemblance to their 2C-x (25I/2C-I) counterparts. Others have reported high levels of vasoconstriction with the 25Xs, higher than their 2C-X counterparts (causing increases in blood pressure). So there's little to no predictive value or reliability in trying to translate from your lack of a bad reaction with PEA to 25I. If you're absolutely set on tripping soon just use a standard tryptamine like a 4-sub (not aMT or 5-MeO-aMT, which release a lot of dopamine, though) or LSD.

Also: sorry, in my last post I thought you were talking about a friend for some reason instead of yourself.

 

[Synaptic Gap]

I will probably just wait a few weeks to get off the selegeline before I do the 25I. I am not saying because I did mescaline and PEA with it that it might be safe. Obviously a substance active at mcg level is a lot more risky. The reason for the post is that I have no idea and just wondering if anyone at has any experience. I am getting some 5-meo-MIPT soon too and that is a tryptamine so I will probably try that first since I should not be inhibiting MAO A at just 5 mg/ day selegeline.

 

[psood0nym]

Sounds good. I'd say even if your MAO-A was inhibited taking something like a 4-sub tryptamine is probably still a lot less risky than taking 25I with just your MAO-B inhibited (mushrooms with MAO A and B inhibitors is fine, for example). The difference is between a stronger, longer, slightly different trip with the former and that plus possibly a hypertensive crisis or other physical emergency with the latter. There's a report of 25B putting a woman in a brief coma within a normal dosage range all by its lonesome, for example.

 

[Synaptic Gap]

Thanks for the advice psood0nym...you sound like you know your stuff.