vecktor said:
Additionally BOM is already widely used scientifically to refer to the benzyloxymethyl not N-benzyl.
Who cares?
OK.
As you may have seen in Nichols writing mentioned in the firt post of the topic, and probably in some older papers, phenylethylamines carrying a behzyl substituent on their nitrogen atom are very selective towards 5-HT2A serotonin receptor. This means we should at least feel less side effects resulting from the activation of a few more pharmacological targets with such a chemical, than there are with just any phenylethylamine from PIHKAL.
Bomamines give almost no side effects in a reasonable dose. Even the appetite is normal. Though to say "none at all" would be unfair, since there is a rise of body temperature and a mild vasoconstriction present. So, you don't feel sick when coming up and throughout the trip. They doesn't drag you towards the earth as PEAs can do, you actually feel lightweighted. Combined with a light motor coordination loss and body scheme disturbance this gives a feeling like howering in zero gravity.
Such structures may also possess sigma activity (see Glennon R. A. Pharmacophore identification for sigma-1 receptor binding: application of the "deconstruction-reconstruction-elaboration" approach. Mini Rev Med Chem. 2005 Oct;5(10):927-40., but this is just a speculation.
It is still fun to raise the dose to the intensities you would not desire with a simple PEA, mostly due to the above mentioned side effects of the latter. But not too far. The ratio of a normal dose to a lethal one probably doesn't differ much if we compare NBOMe and simple PEAs.
Chemicals we are speaking about develop a remarkable tolerance to their and any other psychedelic drugs effects, that may sometimes need about two weeks to trail off. And they are totally inactive when taken orally.
N-(2-methoxybenzyl)-tryptamines and N-methyl-N-(2-methoxybenzyl)-tryptamines are inactive. Most of the 3,4,5-substituted PEAs are also inactive with the exception for NBOMe-mescaline, that require a 50-100 mg dose for a trip. NBOMe-2C-H is active at 5-10 mg. NBOMe amphetamines are about ten times weaker than their phenylethylamine counterparts.
NBOMe-2,5-dimethoxy-4-something-phenylethylamines are so far the most remarkable substances in the group. Some of them are still much like Sasha's PEAs, while others differ in a very surprising ways. To name a few, David's NBOMe-2C-I is a true gem. Basically it resembles PEAs, but is much like acid in some of it's effects, especially in the emotional area. It is full with the deep glowing LSD-like empathy that is uncommon within phenylethylamines. Not all of the bomamines are like that, NBOMe-2C-C is more like DOI and is also a gem, NBOMe-2C-B is much like plain 2C-B, and NBOH-2C-B is simply uninteresting.
The activity of bomamines in humans are sometimes inverted: NBOMe-2C-I requires 500-1000 mkg for a trip, NBOMe-2C-B - 500-800, NBOMe-2C-N - 400-700. The most active one I know about is NBOMe-2C-C with 200-500 mkg. Still, NBOMe-2C-D is less active than all theese, NBOMe-2,4,5-trimethoxy-PEA is many times less active, though I don't know the exact dose. Such SARs are likely a result of combination (if we try to simplify it a little) of the affinity to the receptor and weird pharmacokinetics. NBOMe-2C-C, B and I lasts 8 hours, NBOMe-2C-N - 5 hours, just like their ancestors from PIHKAL. When insufflated or injected i/m, they need a full hour to come up, even 1,5 hours in the case of NBOMe-2C-I. Like DOB and DOI. Thus, they are metabolised very rapidly, and it is clearly not MAO that does that. Looks like in the close series like C, B and I, the faster they get to the brain, the stronger they are.
This nice picture is darkened by the lack of safety when handling such chemicals. No oral activity means it is very tricky to dose them without good scales. And if you remember the bromo-dragonfly story w w w . erowid.org/chemicals/bromo_dragonfly/bromo_dragonfly_death.shtml , you will see that if they will ever become popular, we will undoubtedly hear about accidental deaths associated with their consumption.
BOM!