^^ yeah Dex is subjectively "cleaner" than Add as it lacks the L Amp.
I know exactly what your talking about Dexedrine spansules or Halloween pills as we sometimes called em.
Black & Clear with orange beads or generic ones we often referred to as Pepsi for some odd reason.
Well they were clear & brownish but I think the main reasoning would be that we could be at work call a friend & ask em to bring
some Pepsi down to work without it sounding suspicious.
Oh the memories... but I digress I'm past that now.
Back when I had a bad Dex habit (Oral) I would average around 200mg plus or minus 50mg over the course of a day.
Note I did not start at those kind of doses it took a few years to get up to those kind of doses being a daily thing.
Now that I'm older & wiser I would never subject myself to that again.

Now as for harm reduction as opposed to dick sizing.
The reasoning for posting this would be that my habit ended when I began to have daily seizure's to go along with my Dexedrine doses...
After quitting said habit due to said seizures I had wonderful side effects that took years to go away.
For example teeth grinding in my sleep that was loud enough to wake my gf up.
That particular effect lasted approximately 3-4 years after D-Amp cessation.
Anyways there's my 2 cents on the matter; being that 250mg is way to much.
As for your friend; well his story of taking & "enjoying" that high a dose without a tolerance... 8)
Off Topic Warning: To beagleboy or someone with similar experiences do you find now that you have a reversed tolerance to amps?
I find that since I had the seizures & such & gave up the habit, nowadays (approx 5 years later) I can take tiny amp doses with great effect.
Not just no tolerance level doses even lower.
For example I can feel mild to moderate effects off of a 3.75mg dose with 7.5mg's likely being enough for an all nighter.
Anyone else with a similar Amp history notice they now have a reversed tolerance to Amps?
I apologize for the off-topic question but seeing as OP's question is answered & this will likely be closed due to that fact
I figure I'll try to sneak my question in as I don't feel it warrants it's own thread.