2000 MG apap too much?

[flaker]

4 hydrocodones 7.5/500. Is 2000 MG apap too much for one time - should I use CWE or is it fine at that level?
Thanks all,

 

[ChemicalSmiles]

If you arent using them regularly like that... its fine to dose that much apap. Just dont make it a regular thing.

 

[flaker]

Thanks. Not regular at all. Appreciate the advice.

 

[badfish45]

I'll move this since it really isn't an introduction.

 

[debaser]

Yeah, 2 grams is on the verge of being to far of a game. Don't do that every day, for sure

 

[DistyBoi]

The maximum you should take is about four grams in one dose, you wont do any real damage with that. Just dont take that much often, and certainly dont take that much if you have taken any APAP the days before or will after. The liver usually has enough glutathione stashed away to effectively clear the drug.

It is only when glutathione reserves are depleted by a huge dose of acetaminophen that the concentration of reactive metabolites becomes dangerously high. 4g is quite a lot, as the sudden spike in drug levels will put strain on the liver's antioxidant cache, but not a damaging amount. The liver needs time to replenish glutathione reserves, so you cant keep up doses like this for very long.

 

[aveoturbo]

You should be fine but dont take anymore and learn how to do a CWE if you want to do more

 

[jaurk]

I did it once.. with codeine, a little bit of pain in the lower belly.
Wouldn't do it again, I wouldn't advise it, but can't see it damaging anything.

 

[sekio]

It's fine.

Answered & Closed