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RCs 2-fma vs 2-fa toxicity and effects

B

brjohnson08

Greenlighter
Joined
Feb 16, 2013
Messages
15
I am currently in a position where I can either try 2-fa or 2-fma. I wanted to know how the toxicity and effects of 2-fma compare to 2-fa. From my basic understanding of amphetamines, 2-fma should be somewhat more potent and long lasting, however, it should also be more neurotoxic since it is an analog of methamphetamine. Does anyone know if this holds true? Can 2-fma cause neurotoxicity in the same way that standard methamphetamine can? I was also wondering how their effects compare. I imagine that 2-fma will last longer and be stronger but I am not sure by how much. A comparison with 2-fa would be greatly appreciated here. However, I am most concerned with toxicity. If 2-fma can cause neurotoxic effects in the same way that meth can, I don't think I want to play with it.
 
I think, short-term, no one really knows. Long term, no one really knows. This stuff is so new. It might react very horribly in a certain way to a certain med, but no one's found out yet. This stuff is dangerous. i thought about using 2-FMA as a study aid on a fairly regular basis, then enough people convinced me it is stupid as fuck.
 
I understand that this drug can have significant dangers associated with it. However, I was wondering about a comparison with 2-fa specifically, in terms of both positive and negative effects. Any experience reports would be greatly appreciated.
 
I was also wondering about the relative potencies of the two drugs (2-fa and 2-fma). I wanted to know the doses of each used. Theoretically, 2-fma would need a lower dose, since it is a methamphetamine analog, but I don't know if that translates to the real world because I have heard varying things about the relative dosages of 4-fa and 4-fma. A comparison between the good and bad effects of these chemicals would be great because there is so little information on the internet comparing these two.
Thanks
 
I can't comment on the potential toxicity of either drug but I found 2-fma to feel much more subtle than 2-fa, 2-fa feels very similar to d-amphetamine. It's very stimulating but slightly less euphoric where as 2-fma just gave me a little pick me up. Both proved to be good study aides but 2-fma seemed to be easier on the mind and body if taken on a regular basis

Here is some speculation about the neurotoxicity of 2-FA from the mega thread:


I'm no expert on Chemistry myself (my area is Physics) but what I do know is that most halgenated amphetamines cause serious drops in serotonin levels for a long period after use (a sure sign of neurotoxicity), and that this effect isn't seen in 4-FA. I cannot comment with certainty on 2-FA as I've not seen any studies on it myself. But from my own research, it has no serotonergic (or very low serotonergic) activity itself and even with repeated use shows no signs of serotonin depletion in the days following. Even 4-FA gives me a serotonin dip a few days later if I use too much or use it on consecutive days, although this effect is mild at best unlike overdoing it with MDMA or 4-MMC.

If it is neurotoxic, I suspect it will be in classic amphetamine way as opposed to the non-MAOB, some-other-serious-free-radical way of the other halogenated amphetamines. I'd put my my money on it being due to halogenated versions of alpha-methyldopamine if I were a betting man (one of the main neurotoxins common to your usual amphetamines). I've read somewhere that 4-fluoro-alpha-methyldopamine may be less neurotoxic than a-methyldopamine, which may explain the lack of negative after affects from 4-FA.
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The long term effects of fluoroamphetamines have not been followed.

It is reasonable to assume that the pharmacology of 2-fa and 2-fma are equivalent to amphetamine and methamphetamine, respectively. Just keep in mind most of the fluoroamphetamines sold today are racemic mixtures; pharmaceutical amphetamines are dextro-enriched (Adderall) or all dextro-isomers (Desoxyn, Dexedrine), which are the more centrally active isomers.
 
I've been a sporadic 2-FMA user (dosing generally up to 50mg) for several months, and have noticed no lasting effects.

Side effects have been bruxism and slight hypertension, both to a much lower degree than the same dose of unfluorinated meth.

Subjective effects of 2-FMA are overall a lot more similar to d-amp than d-meth, and certainly very far from racemic meth. I would actually say its effect profile is somewhat more similar to Armodafinil than d-amp, but still shares some properties.

The one thing that is quite certain from all the reading I've done is that in-vivo formation of fluoride ions is absolutely not something to worry about, despite previous speculation on this. I just personally wouldn't smoke it, as this may be a different story.
 
I'm not so much concerned with fluoride ions as I am concerned about the toxicity associated with it being a methamphetamine analog. I know that methamphetamine is neurotoxic while standard amphetamine is not and I was wondering about how this would compare with the 2-fluorinated version. My intuitive feeling is that 2-fma should be less neurotoxic than standard methamphetamine because 2-fa seems less selective for dopamine than amphetamine and there seems to be less euphoria with 2-fma than methamphetamine which would indicate less dopaminergic activity. However, this is all speculation and I don't have any hard data to back me up. I know not to expect any hard data since this chemical is so untested, but some more reports from people who have used both chemicals would be great.
Thank you
 
That article about methamphetamine being neuroprotective at low doses was very interesting. I knew that regular amphetamine was neurotoxic at high enough doses but I didn't know that meth could be neuroprotective at any dose. Any idea on how the doses used in the study would translate into human doses? I also had some questions regarding the comparison of 2-fma and 2-fa, primarily, which of the two needs a smaller dose and which one lasts longer? I assume that 2-fma lasts longer based on what I have read and considering that it is likely metabolized to 2-fa therefore acting as a sort of extended release 2-fa. I also assume that 2-fma would need a lower dose than 2-fa since that extra methyl group would help it get through the blood brain barrier more efficiently. Again, both of these ideas are just speculation with no data to back me up but these theories make sense to me. If anyone can either support or object to what I have written here, that would be great.
 
2-fma definitely lasts way longer than regular MA or amp for me. One 20-30mg sniff and I can be wired for 8 hours, with inability to sleep lasting beyond that. I got pretty deep into 2-fma for a solid 4 months while I was working a high stress physical labor job. It screwed with my sleep, and somewhat with my cognitive function but beyond that I didnt notice anything different negatively between 2-fma and regular amp use. As a matter of fact, regular amp is much more rushy and euphoric than 2-fma. 2-fma is an extremely functional stim, especially when taken orally at the right doses. Snorting it can lead to moreish-ness, which isnt a good thing because of how long lasting it is. You can easily get over-stimulated for way too long periods of time.

When you go on a 3 day binge off of methamp or amp, you go into a grimey "funk" by the second day. 2-fma doesnt even put you in that funk, sure youll be tired and out of it in the head, but none of the grimey/dirty dream state that amp puts you in after 3 days. Again, I found 2-fma less euphoric than amp or methamp, but its sure one of the best functional stims Ive ever tried.

The only downside I noticed, was that with amp and methamp, the high is very "clear headed" at least for me. 2-fma was pretty darn close, but put me in a weird mindstate that is very hard to explain. It was more clear to me (the user) that I was on a drug. I cant put my finger on it, it wasnt more empathogenic or anything, but shifted my mental state moreso than normal amphetamines. Perhaps the 2-position on the benzene ring causes some sort of minor change in effects?

I have yet to try 2-fa because Im "trying" to take a substantial break from stim and drug use in general, but Im really curious as to how it is. If its a shorter lasting 2-fma, it may be a real winner.

I never noticed any negative physical effects besides sleep deprivation. I get way more negative physical effects from regular amp, methamp, and cathinones. I dont know the science behind why this is, but it was definitely nice. I cant comment on the toxicity, but I never had any heart issues, vasoconstriction issues or brain issues. After stopping usage for 1.5 weeks I lost all cravings for the drug, and felt back to baseline. Only issue was smoking weed on 2-fma, cause my heart to race like no other, but that is to be expected.
 
I just tried 2-fma at about 60mg last night. I would say it is a little more than 1/10th the potency of d-amp; the effects were greater than 5mg d-amp, but not greater than 10mg. I haven't taken a fully effective dose of 2-fa yet, but I can attest that 2-fma lasts a bit longer than 2-fa and d-amp. Nonetheless, I was able to sleep about 8 hours after swallowing it. I thought the euphoria was similar to d-amp - just enough to get you into taking care of business. As gcaudios said, there is a subtle feeling of being "on drugs" that is a little distinct from d-amp, but pleasant - reminscent of 4-fa, but without that rolly feel that often characterizes the first couple hours of 4-fa. This is clearly more of a nootropic, with no real serotonergic or adrenergic effects. I found myself to be motivated and clear-headed, with a heightened ability to stick with my primary goal even in the presence of distractions. Even with d-amp I sometimes find myself getting sidetracked and focused on playing guitar or whatever, but last night I was pretty on-task.
Side effects: It did get my heart going a little faster and harder, and made my armpits sweaty, but there was none of the anxiety that can often accompany these side effects! It was very smooth in that sense, and I am quite sensitive to stimulant side effects. I generally do quite well with d-amp, but I can't even handle caffeine for the most part. During the main effects, I also had a slight feeling in my head that might have been a headache if it was magnified a couple times - it felt like it was probably cardiovascular-ly related.
I can't speak to the safety of getting crazy with this stuff or using it daily, but at this dosage I didn't experience anything disconcerting, other than the godawful taste. It really does taste like it shouldn't be consumed, but so do lots of other drugs, I guess. That aside, it is the best nootropic option I have come across, right up there with d-amp. Too bad it isn't more potent.
p.s. Sorry I couldn't compare with 2-fa. I've heard pretty similar things about that.
 
Last edited:
bennyZA said:
SERIOUS 2-FMA HEALTH WARNING:

So I think this is really important to tell people, in fact I would have made a thread just for this news I got from my friend, maybe this post will be split off if a mod thinks it should be... but... MASSIVE WARNING ON USING 2-FMA AS A REGULAR STUDY DRUG

I want to preface this by saying I don't know shit about biology and barely anything about organic chemistry (other than what most druggies know) and that my friend i will be speaking about is also not an expert in either subject, so please feel free to correct me if I say something stupid (Sekio, I'm looking at you buddy) but in the end, 2-FMA is directly responsible for potentially fatal heart issues.

So a friend of mine lost his adderall script so he decided to try 2-FMA, he said it was absolutely amazing, made life easier in general So he started taking it like he used to take adderall. He said that he felt better overall, was able to get more done, was able to take on much more than simple amphetamines ever let him, in fact, he would talk for hours about how 2-FMA should be the new adderall of the future...

Well, he has now had 2 heart surgeries in 2 weeks due to a severe heart arrhythmia and some other complication I can't remember. It was caused by large amounts of toxic 'amphetamine like substances' that had been accumulating in his fatty tissue and eventually began to effect his peripheral nervous system and heart without him realizing it. It's actual similar to normal amphetamine overuse but the 'amphetamine like substances' released slowly were severely cardio-toxic byproducts of 2-FMA. At first they couldn't figure out what was wrong cause he wouldn't admit to using an RC on a regular basis. Finally he realized he had to tell them and supposedly these byproducts of 2-FMA accumulate much more over time than normal amphetamines, are released even more slowly, and are much more toxic. Eventually his heart basically began to short circuit without him even realizing anything was wrong until he collapsed. Not only did he have to get emergency surgery for the arrhythmia but he had to get some other massively invasive procedure today for some other problem it caused to his heart. He is lucky he's alive at this point, and frankly, all of us - his friends - are freaking out because we'll know in 3 weeks whether they fixed his heart for good or not.

tl;dr: My buddy basically summed up that if you take 2-FMA as regularly as he did (daily for probably about a year) cardio-toxic phenethylamines build up so slowly in your body to the point where you don't even notice the effects until there is enough of these toxic chemicals to cause serious heart damage.

Oh, and btw, his newest doctor is one of the few RC experts and is actually going to use my friend in a study and is positive it is from 2-FMA because the only other drugs he's done in the last year were weed and caffeine (he does not drink).

I also want to point out I have no dog in this race. In fact, I was about to go on a regular 2-FMA 'diet.' Either way, I don't care what you do, but 2-FMA - for sure - fucked up my friends heart and we are not sure what's going to happen.

Please, if you are religious say a prayer for my friend. I think everyone should use this time to reflect on the dangers of regular RC use. As much as I hate them, the FDA exists for precisely this reason. Please spread the message that 2-FMA can cause this problem.

Again, my biology or pharmacology info may be wrong so please feel free to point out any mistakes.
http://www.bluelight.org/vb/threads/648663-Best-stimulant-RC-Study-Aid/page2

DON'T FUCK WITH 2-FMA; Stick with PHARM grade stims.
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