Neuroborean
Bluelight Crew
- Joined
- Nov 15, 2020
- Messages
- 1,501
My problem is task-starting, much more than sustained attention, except for super boring tasks like studying or reading/doing something I hate (like paperwork)Task-starting and sustained attention are different beasts for sure. When I was finishing my dissertation, dextroamphetamine definitely provided both, along with some of the mood lift, bordering on euphoria. The mood lift makes starting tasks less daunting, and the tunnel vision/hyperfocus help keep effort consistent.
Are you saying you think 2-FMA is worse for you because it's a stronger dopamine releaser? My understanding has been, lacking actual binding profile studies, racemic 2-FMA is probably actually a stronger NE releaser than d-amph, which in turn is stronger than d-meth. I haven't seen anyone even speculate as to enantiomer-specific activity of 2-FMA, but pulling things out of thin air, I would guess, as with meth, the l-enantiomer of 2-FMA is extremely biased towards NE, and the d-enantiomer is more balanced. This would explain the apparent ceiling effect of 2-FMA. Since reports are that high doses increase vasoconstriction and tachycardia without more central stimulation, it would make sense that racemic 2-FMA, which as far as I know is all anyone has ever taken (correct me if I'm wrong), would be NE biased as a single drug. 2-FMA is also less associated with psychosis and mania in user reports, which suggests less dopamine bias. This could all be complicated by metabolism—there's a paper on plausible metabolites of 2-FMA, but as with its binding potency, the literature is sparse.
I do agree that dopamine release is not strictly better for ADHD pharmacotherapeutics. Most anecdotes I've read about attempts to use d-meth for ADHD suggest that it can be counterproductive, but more so because of the heightened euphoria. I view mood lift as something that needs to be optimized: enough to overcome task anxiety and increase task enjoyment, but not so much you stop worrying at all about the actual life obligation ADHD is interfering with. I also personally wonder if the apparent anxiolysis along with more subtle stimulation of 2-FMA might be due to interactions with sigma receptors, or maybe a relative lack thereof compared to meth. Since 2-FMA is unlikely to be enough of a cash cow to merit clinical trials, and hasn't been the subject of alarmist media reporting, I think the motivation to do binding assays on it is weak, and so insight about its pharmacology is likely to continue only at a trickle.
Good luck in any case with your research and writing. It's not the easiest thing for those of us with ADHD diagnoses, and optimizing medication goes a long way to help with that.
I guess that I don't respond well to NE releasers, but that's not the case with NE reuptake inhibitors... for me yohimbe feels pretty nice, I feel very motivated while on yohimbe, but I'm totally unfocused, same with NEP which seems to be pretty potent on NE ...
I do consider 2-fma useless but I remember that my first batch was pretty nice, and it worked nicely, but it was much more euphoric.... So, what was that? who knows, I guess we are receiving poison from China/India and not actually any pure racemic anything, let alone pure l-/d-enantiomers...
I also think you're right about euphoria and mood lift, too much is too distracting, but not enough makes everything robotic and boring, and 4f-mph and specially late batches of 2-fma feel too robotic for me , boring as fuck (but I much prefer 4f-mph as functional adhd medication).
3-mmc after peak effects would be the perfect adhd medication for me but obviously it's too much serotonin to waste daily...
The problem is that any dopamine releasers that create serious task-starting inducing euphoria doesn't seem sustainable long term in terms of subjective effects... for example kratom could be euphoric for a bit more than a year, taking daily, but after that... it's "something" but not enough to induce starting tasks....
In anycase, I subjectively feel 2-fma more much dopamine dominant than 2-FA or 4f-mph, but yeah, you could be right and perhaps it's the sigma fuckery what feels so zombieish, I don't like that feeling to be honest, I only enjoy the 2-fma "rush", if we can call it that way..., the comeup, maybe?