5/12/10
Powder on end of small spatula. Oral. 10:30am
Taste is bitter with an unusual flavour.
2 minutes of sublingual absorption before swallowing.
t=3 occasional awareness of altered headspace when sitting. No other noticeable effects. Appetite seems very mildly inhibited. Have cleaned room, but no very noticeable stimulation or other effects.
t=5 appetite is unsupressed, and may never have been
same effects as before but no altered headspace.
t=7 no increased desire to work or other effects, any changes in ability to work are insignificant.
t=9 no effects
quantities at this point were volumetrically measured in water and dried. (75mg in 30mls tap water, took approx 48hrs to dry)
11/12/10
~5mg dissolved in water. Oral. 12:15pm
t=0 bpm 67
t=1 miniscule headache
t=1:45 miniscule nausea, likely unrelated. feeling fast.
again, limited increased concentration ability (CA herein), however there is no certainty that this is a result of the drug
able to sleep without issue.
12/12/10
~5mg dissolved in water. oral. 12:30pm
no exercise all day (factor in insomnia). Possibly of note is excessive consumption of tarragon and star anise throughout day. (MAOI activity not studied, but in vivo conversion to PMA which is a strong MAOI)
effects were not as noticeable as before. again, insignificant CA increase (p=.50)
around t=11 mild clenching of the jaw was noticed, likely to have been occurring since t=10.
t=13.5 sleep attempted. Relaxed, but unable to sleep and little if any tiredness.
t=14 0.9mls GBL administered.
t=15.5 still awake and not particularly tired. Also hungry, but no desire to eat food. Further 1.2mls GBL administered, small amount of food eaten quells hunger. BPM64
t=16.75 still not particularly tired. 2.0mls of GBL administered.
t=17 effects of GBL are noticeable.
t=17.5 still awake but sedation very noticeable from GBL
t=19.5 disturbed and feel like sleeping again will not be possible. No further thoughts recalled, suggesting immediate return to sleep (possibly a dream?).
t=21.5 awaken and try to sleep more. after 10mins bed is left to use toilet. do not feel tired, and feel that attempting sleep will be futile.
t=23 bread, milk and eggs eaten. not especially hungry as would be predicted from lack of food in last 24hrs.
t=23.5 lecture attended significant CA increase, possibly because of drug (p=0.75) some mistakes made, but feeling "on the ball"
t=25.5 still not tired or feeling particularly run-down.
t=30. BPM 80. feel a little tired.
t=32 general discomfort. feeling tired.
t=34 bpm 80
t=38 GBL (2.3mls) administered over 1 hour to induce sleep. slept for 5.5 hours.
t=45 bpm between 80 and 90 while semi active during day. uncomfortable at times. Very sweaty despite being cool. Shivering when only a bit cold.
t=54 bpm 80 urinary retention noticed. In retrospect, thirst and urination have been minimal over the last few days.
In summary, I took 5mg two days in a row, and have been unable to sleep for 2 nights.
I ate a considerable amount of tarragon (estragole) which I believe may have caused more problems by in vivo conversion to PMA)
I had a tight jaw on day 2 and 3, and still have a high bpm (end of day 3)
It seems like the effects were worst about 12 hours after the second dose.
What's caused this?
My theory is that the combination of long half-life with the foolish 2-day dosing have caused severe urinary retention, and this has considerably extended the effects. I think that the PMA contributed, but did not extend (it is an MAOI, but dpmp doesn't really get metabolised, just excreted)
Is urinary retention common with desoxy?
Could estragole convert to PM in vivo?
Is the extra strain on my heart (33% increase) likely to be causing damage?
Edit: something I hadn't considered. On day 1 I took 800mg piracetam, on day 2; 2400, on day 3; 1600 (have stopped for a while in case this is contributing)
Sounds like some other desoxypipradol stories I've heard.
Estragole is metabolized in vivo to PMA? That's interesting... are you sure you aren't thinking of anethole? Which is a precursor to PMA. I wouldn't ingest estragole, seeing as it's probably a carcinogen. I can't find anything about metabolizing estragole into PMA, do you have any links?
It's a theory based on speculation, I did have a quick search but it didn't turn up anything authoritative.
Estragole is the double bond isomer of anethole, so it's quite possible. I also had a fair amount (less than the estragole though) of anethole from star anise, so either or neither could be the culprit.
I know that they are both potentially harmful pure, but I don't think they present a serious risk of carcinogenicity.
.dp I'm aware that I made a mistake, I think most people do occasionally. I was looking for more constructive comments, but everyone is entitled to their opinion.
5mg was not my initial dose.
I did sleep perfectly before redosing 24h later.
After consuming a lot of water and urinating appropriately, my heart rate returned to normal and I was able to sleep normally.
It's a theory based on speculation, I did have a quick search but it didn't turn up anything authoritative.
Estragole is the double bond isomer of anethole, so it's quite possible. I also had a fair amount (less than the estragole though) of anethole from star anise, so either or neither could be the culprit.
I know that they are both potentially harmful pure, but I don't think they present a serious risk of carcinogenicity.
I can't find any evidence online for either being metabolized in vivo to PMA... anethole can be metabolized by certain bacteria into aromatic compounds though.
Also going against the PMA hypothesis is that administration of anethole can lead to lowering of body temperature; the opposite of what PMA is known for.
